peramivir

REMS

Treatment of acute uncomplicated influenza in patients who have had symptoms for 2 days or less.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Hypersensitivity.

Use Cautiously in:

Renal impairment (dose ↓ required for CCr <50 mL/min);
OB: Use during pregnancy only if potential maternal benefit justifies potential fetal risk;
Lactation: Use while breastfeeding only if potential maternal benefit justifies potential risk to infant;
Pedi: Children <6 mo (safety and effectiveness not established); ↑ risk of neuropsychiatric events;
Geri: Consider age-related ↓ in hepatic, renal, cardiac function, concurrent diseases and drug therapy.

Adv. Reactions/Side Effects ⬆ ⬇

CV: hypertension

Derm: ERYTHEMA MULTIFORME, STEVENS-JOHNSON SYNDROME

GI: constipation

Neuro: insomnia, neuropsychiatric events

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS)

Interactions ⬆ ⬇

Drug-drug:

Avoid use of live attenuated influenza vaccine within 2 wk prior and 48 hr after peramivir; interference may occur.

Availability ⬆ ⬇

Solution for injection: 10 mg/mL

Route/Dosage ⬆ ⬇

IV (Adults and Children ≥13 yr): 600 mg as single dose.
IV (Children 6 mo–12 yr): 12 mg/kg (max = 600 mg) as single dose.

Renal Impairment

IV (Adults and Children ≥13 yr): CCr 30–49 mL/min: 200 mg as single dose; CCr 10–29 mL/min: 100 mg as single dose.

Renal Impairment

IV (Children 2–12 yr): CCr 30–49 mL/min: 4 mg/kg (max = 600 mg) as single dose; CCr 10–29 mL/min: 2 mg/kg (max = 600 mg) as single dose.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Inhibits the enzyme neuraminidase, which may alter virus particle aggregation and release.

Therapeutic effects:

Reduced duration or prevention of flu-related symptoms.

Classifications ⬆ ⬇

Therapeutic Classification: antivirals

Pharmacologic Classification: neuraminidase inhibitors

Pharmacokinetics ⬆ ⬇

Absorption: IV administration results in complete bioavailability.

Distribution: Unknown.

Metabolism/Excretion: Mostly eliminated unchanged by kidneys (> 90%).

Half-Life: 20.8 hr.

Time/Action Profile ⬆ ⬇

(blood levels)

ROUTE	ONSET	PEAK	DURATION
IV	rapid	end of infusion	unknown

Patient/Family Teaching ⬆ ⬇

Explain purpose of peramivir to patient.
Advise patient to notify health care professional if signs and symptoms of anaphylaxis or rash, or neuropsychiatric symptoms occur.
Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

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Indications ⬇