Prevention of oropharyngeal candidiasis in immunocompromised patients (receiving chemotherapy or radiation for cancer or corticosteroids for cancer or transplant).
Contraind./Precautions⬆⬇
Contraindicated in:
Hypersensitivity to clotrimazole or other components of formulation;
Systemic candidiasis.
Use Cautiously in:
Hepatic impairment;
OB: Use only if potential benefit justifies potential risk to fetus;
Pedi: Children <3 yr (safety and effectiveness not established).
Adv. Reactions/Side Effects⬆⬇
Derm: pruritis
GI: ↑liver function tests, abnormal mouth sensations, nausea, vomiting
PO (Adults and Children ≥3 yr): Treatment: One troche 5 times daily for 14 days; Prophylaxis: One troche 3 times daily for the duration of chemotherapy or until steroid doses are reduced to maintenance levels.
US Brand Names⬆⬇
Mycelex
Action⬆⬇
Affects the permeability of the fungal cell wall, allowing leakage of cellular contents.
Therapeutic effects:
Decrease in or prevention of symptoms of oropharyngeal candidiasis.