crofelemer

REMS

Symptomatic relief of noninfectious diarrhea in HIV-infected patients currently receiving antiretroviral therapy.

Contraindicated in:

Use Cautiously in:

EENT: nasopharyngitis

GI: ↑liver function tests, abdominal distention, flatulence, hemorrhoids, nausea

GU: urinary tract infection

MS: arthralgia, back pain, musculoskeletal pain

Neuro: anxiety

Resp: bronchitis, cough, upper respiratory tract infection

Drug-drug:

Mytesi

A natural product derived from Croton lechleri, a species of flowering plant.
Inhibits cyclic adenosine monophosphate-stimulated cystic fibrosis transmembrane conductance regulator chloride ion channels and the calcium-activated chloride channels on luminal membranes of enterocytes. Blocks chloride secretion and water loss by inhibiting chloride channels on the membranes of enterocytes.

Therapeutic effects:

Therapeutic Classification: antidiarrheals

Pharmacologic Classification: catechins

Absorption: Minimal absorption following oral administration.

Distribution: Unknown.

Metabolism/Excretion: Unknown.

Half-Life: Unknown.

ROUTE	ONSET	PEAK	DURATION
PO	unknown	unknown	unknown

Instruct patient to take crofelemer as directed.
Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected and to avoid breastfeeding.

kro-FEL-e-mer