silver sulfadiazine

REMS

Prevention and treatment of wound sepsis in patients with 2nd- and 3rd-degree burns.

Unlabeled Use:

Contraindicated in:

Use Cautiously in:

Derm: burning, EXFOLIATIVE DERMATITIS, itching, pain, rash, skin discoloration, skin necrosis, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS

Hemat: leukopenia

Drug-drug:

(Generic available)

(Adults and Children >1 mo): Apply 1% cream 1–2 times daily in layer 1.5-mm thick.

Flint SSD, Sildimac, Silvadene, Thermazene

Therapeutic effects:

Spectrum:

Broad spectrum includes activity against many gram-negative and gram-positive bacteria, anaerobes, and some yeast.

Therapeutic Classification: anti-infectives (topical)

Pharmacologic Classification: sulfonamides

Absorption: Small amounts of silver are systemically absorbed following topical application. Up to 10% of sulfadiazine is absorbed.

Distribution: Unknown.

Metabolism/Excretion: Absorbed sulfadiazine is excreted unchanged by the kidneys.

Half-Life: Unknown.

Dermazin, Flamazine

(anti-infective action)

ROUTE	ONSET	PEAK	DURATION
Topical	on contact	unknown	as long as applied

Explain purpose of medication to patient and family. This medication will not stain skin.
Advise patient to promptly notify health care provider if rash occurs.

SIL-ver sul-fa-DYE-a-zeen