section name header

Indications ⬇

High Alert

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Side effects primarily caused by LHRH antagonist

CV: edema, hypertension

Derm: photosensitivity, rash

Endo: gynecomastia, hot flushes

GI: diarrhea, nausea, vomiting, HEPATOTOXICITY

GU: erectile dysfunction, loss of libido

Neuro: anxiety, confusion, drowsiness, mental depression, nervousness

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

  • Capsules: 125 mg; 250 mg

Route/Dosage ⬆ ⬇

  • PO (Adults ): 250 mg every 8 hr.

US Brand Names ⬆ ⬇

Eulexin,

Action ⬆ ⬇

  • Antagonizes the effects of androgen (testosterone) at the cellular level.
Therapeutic effects:
  • Decreased growth of prostate carcinoma, an androgen-sensitive tumor.

Classifications ⬆ ⬇

Therapeutic Classification: antineoplastics

Pharmacologic Classification: antiandrogens

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed after oral administration.

Distribution: Unknown.

Metabolism/Excretion: Mostly metabolized by the liver. Some conversion to another antiandrogenic compound (2-hydroxyflutamide).

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

ROUTEONSETPEAKDURATION
POunknownunknownunknown

 



Patient/Family Teaching ⬆ ⬇

  • Explain that flutamide must be taken in conjunction with leuprolide. Instruct patient to take flutamide exactly as directed. If a dose is missed, take as soon as possible unless almost time for next dose. Do not double doses.
  • Warn patient that side effects such as hot flashes, loss of sex drive, erectile dysfunction, and breast enlargement may be caused by the LHRH agonist. The primary side effect of flutamide alone is diarrhea, but the combination of drugs is necessary to achieve the therapeutic effect.
  • Advise patient to notify health care provider immediately if dark urine, itching, loss of appetite, nausea, vomiting, pain in right side, or yellow eyes or skin occurs. Hepatotoxicity usually resolves when flutamide is discontinued, but it may be progressive and fatal; requires immediate medical attention.

Pronunciation ⬆

FLOO-ta-mide