phenelzine

REMS

Neurotic or atypical depression (usually reserved for patients who do not tolerate or respond to other modes of therapy [e.g., tricyclic antidepressants, SSRIs, SNRIs, electroconvulsive therapy]).

Contraindicated in:

Hypersensitivity;
Liver disease;
Severe renal impairment;
Pheochromocytoma;
HF;
Patients undergoing elective surgery requiring general anesthesia (should be discontinued ≥10 days before surgery);
Excessive consumption of caffeine;
Concurrent use of meperidine, SSRIs, SNRIs, tricyclic antidepressants, tetracyclic antidepressants, nefazodone, trazodone, procarbazine, selegiline, linezolid, carbamazepine, cyclobenzaprine, bupropion, buspirone, sympathomimetics, other MAO inhibitors, dextromethorphan, narcotics, alcohol, general anesthetics, diuretics, or tryptophan;
Concurrent use of foods containing high concentrations of tyramine (see Food Sources for Specific Nutrients).

Use Cautiously in:

May ↑ risk of suicide attempt/ideation especially during early treatment or dose adjustment; this risk appears to be greater in adolescents or children;
Schizophrenia;
Bipolar disorder;
Seizure disorders;
Diabetes (↑ risk of hypoglycemia);
OB: Safety not established in pregnancy;
Lactation: Safety not established in breastfeeding;
Pedi: Safety and effectiveness not established in children;
Geri: ↑risk of adverse reactions in older adults.

CV: edema, orthostatic hypotension, HYPERTENSIVE CRISIS

Derm: pruritus, rash

EENT: blurred vision, glaucoma, nystagmus

F and E: F and E, hypernatremia

GI: constipation, dry mouth, ↑liver enzymes, abdominal pain, nausea, vomiting

GU: sexual dysfunction, urinary retention

Metab: weight gain

Neuro: dizziness, drowsiness, fatigue, headache, hyperreflexia, insomnia, tremor, twitching, weakness, euphoria, paresthesia, restlessness, SEIZURES, SUICIDAL THOUGHTS/BEHAVIORS

Drug-drug:

Serious, potentially fatal adverse reactions may occur with concurrent use of other antidepressants (SSRIs, SNRIs, bupropion, tricyclics, tetracyclics, nefazodone, trazodone), carbamazepine, cyclobenzaprine, procarbazine, or selegiline. Avoid using within 2 wk of each other (wait 5 wk from end of fluoxetine therapy).
Hypertensive crisis may occur with amphetamines, levodopa, dopamine, epinephrine, norepinephrine, methylphenidate, or vasoconstrictors.
Hypertension or hypotension, coma, seizures, respiratory depression, and death may occur with meperidine; avoid using within 2–3 wk of MAO inhibitor therapy.
Dextromethorphan may produce psychosis or bizarre behavior.
Hypertension may occur with buspirone; avoid using within 2 wk of each other.
Additive hypotension may occur with antihypertensives, spinal anesthesia, opioids, or barbiturates.
Additive hypoglycemia may occur with insulins or oral hypoglycemic agents.
Risk of seizures may be ↑ with tramadol.

Drug-Natural Products:

Serious, potentially fatal adverse effects (serotonin syndrome) may occur with St. John's wort and SAMe.
Hypertensive crises may occur with large amounts of caffeine-containing herbs (cola nut, guarana, or malt).
Insomnia, headache, tremor, hypomania may occur with ginseng.
Hypertensive crises, disorientation, and memory impairment may occur with tryptophan or supplements containing tyrosine or phenylalanine.

Drug-Food:

Hypertensive crisis may occur with ingestion of foods containing high concentrations of (see Food Sources for Specific Nutrients).
Consumption of foods or beverages with high content ↑ the risk of hypertension and arrhythmias.

PO (Adults ): 15 mg 3 times daily; ↑ to 60–90 mg/day in divided doses; after maximal benefit achieved, gradually ↓ to smallest effective dose (15 mg/day or every other day).

Inhibits the enzyme monoamine oxidase, resulting in an accumulation of various neurotransmitters (dopamine, epinephrine, norepinephrine, and serotonin) in the body.

Therapeutic effects:

Improved mood.

Therapeutic Classification: antidepressants

Pharmacologic Classification: monamine oxidase inhibitors

Absorption: Well absorbed from the GI tract.

Distribution: Unknown.

Metabolism/Excretion: Metabolized by the liver; excreted in urine as metabolites and unchanged drug.

Half-Life: 12 hr.

( antidepressant effect)

ROUTE		ONSET		PEAK		DURATION
PO		2–4 wk		3–6 wk		2 wk

Instruct patient to take medication as directed. Take missed doses if remembered within 2 hr; otherwise, omit and return to regular dosage schedule. Do not discontinue abruptly as withdrawal symptoms (nausea, vomiting, malaise, nightmares, agitation, psychosis, seizures) may occur.
Caution patient to avoid alcohol, CNS depressants, OTC drugs, and foods or beverages containing tyramine (see Food Sources for Specific Nutrients) or excessive caffeine during and for ≥2 wk after therapy has been discontinued; they may precipitate a hypertensive crisis. Instruct patient to notify health care provider immediately if symptoms of hypertensive crisis (severe headache, palpitations, chest or throat tightness, sweating, dizziness, neck stiffness, nausea, vomiting) develop.
Advise patient, family, and caregivers to look for suicidality, especially during early therapy or dose changes. Notify health care provider immediately if thoughts about suicide or dying, attempts to commit suicide, new or worse depression or anxiety, agitation or restlessness, panic attacks, insomnia, new or worse irritability, aggressiveness, acting on dangerous impulses, mania, or other changes in mood or behavior.
May cause dizziness or drowsiness. Caution patient to avoid driving and other activities requiring alertness until response to medication is known.
Caution patient to change positions slowly to minimize orthostatic hypotension. Older adults are at ↑ risk for this side effect.
Instruct patient to consult with health care provider before taking any new prescription, OTC, or herbal product.
Advise patient to notify health care provider if dry mouth, urinary retention, or constipation occurs. Frequent rinses, good oral hygiene, and sugarless candy or gum may ↓ dry mouth. An ↑ in fluid intake, fiber, and exercise may prevent constipation.
Advise patient to notify health care provider of medication regimen before surgery. If possible, therapy should be discontinued at least 2 wk before surgery.
Instruct patient to carry identification describing medication regimen at all times.
Emphasize the importance of participation in psychotherapy if recommended by health care provider and follow-up exams to evaluate progress. Ophthalmologic testing should also be done periodically with long-term therapy.
Rep: Advise women of reproductive potential to notify health care provider if pregnancy is planned or suspected or if breastfeeding.

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Indications ⬇

Contraind./Precautions ⬆ ⬇

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Classifications ⬆ ⬇

Pharmacokinetics ⬆ ⬇

Time/Action Profile ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆