Addison disease, or adrenocortical insufficiency, occurs when the adrenal cortex function is inadequate to meet a patient's need for cortical hormones. Autoimmune or idiopathic atrophy of the adrenal glands is responsible for the vast majority of cases. Other causes include surgical removal of both adrenal glands or infection (tuberculosis or histoplasmosis) of the adrenal glands. Inadequate secretion of adrenocorticotropic hormone (ACTH) from the primary pituitary gland also results in adrenal insufficiency. Therapeutic use of corticosteroids is the most common cause of adrenocortical insufficiency. Symptoms may also result from sudden cessation of exogenous adrenocortical hormonal therapy, which interferes with normal feedback mechanisms.
Addison disease is characterized by muscle weakness, anorexia, GI symptoms, fatigue, emaciation, dark pigmentation of the mucous membranes and skin, hypotension, low blood glucose, low serum sodium, and high serum potassium. The onset usually occurs with nonspecific symptoms. Mental changes (depression, emotional liability, apathy, and confusion) are present in 20% to 40% of patients. In severe cases, disturbance of sodium and potassium metabolism may be marked by depletion of sodium and water and severe, chronic dehydration.
Addisonian Crisis
With disease progression and acute hypotension, addisonian crisis develops and is characterized by the following:
- Cyanosis and classic signs of circulatory shock: pallor, apprehension, rapid and weak pulse, rapid respirations, and low blood pressure
- Headache, nausea, abdominal pain, diarrhea, confusion, and restlessness
- Slight overexertion, exposure to cold, acute infections, or a decrease in salt intake possibly leading to circulatory collapse, shock, and death
- Stress of surgery or dehydration from preparation for diagnostic tests or surgery possible triggers for addisonian or hypotensive crisis
Immediate treatment is directed toward combating circulatory shock:
- Restore blood circulation, administer fluids and corticosteroids, monitor vital signs, and place patient in a recumbent position with legs elevated.
- Administer IV hydrocortisone followed by 5% dextrose in normal saline.
- Vasopressor amines may be required if hypotension persists.
- Antibiotics may be given if infection has precipitated adrenal crisis.
- Oral intake may be initiated as soon as tolerated.
- If adrenal gland does not regain function, lifelong replacement of corticosteroids and mineralocorticoids is required.
- Dietary intake should be supplemented with salt during times of GI losses of fluids through vomiting and diarrhea.
Assessing the Patient
- Focus the health history and exam on presence of symptoms of fluid imbalance and stress.
- Monitor blood pressure and pulse rate as the patient moves from a lying, sitting, and standing position to assess for inadequate fluid volume.
- Assess skin color and turgor.
- Assess history of weight changes, muscle weakness, and fatigue.
- Ask patient and family about onset of illness or increased stress that may have precipitated crisis.
Monitoring and Managing Addisonian Crisis
- Monitor for signs and symptoms indicative of addisonian crisis, which can include shock; hypotension; rapid, weak pulse; rapid respiratory rate; pallor; and extreme weakness.
- Advise patient to avoid physical and psychological stressors such as cold exposure, overexertion, infection, and emotional distress.
- Immediately treat patient in addisonian crisis with IV administration of fluid, glucose, and electrolytes, especially sodium; with replacement of missing steroid hormones; and with vasopressors.
- Anticipate and meet patient's needs to promote return to a precrisis state.
Restoring Fluid Balance
- Encourage the patient to consume foods and fluids that assist in restoring and maintaining fluid and electrolyte balance.
- Along with the dietitian, help the patient to select foods high in sodium during GI tract disturbances and in very hot weather.
- Educate the patient and family to administer hormone replacement as prescribed and to modify the dosage during illness and other stressful situations.
- Provide written and verbal instructions about the administration of mineralocorticoid (Florinef) or corticosteroid (prednisone) as prescribed.
Improving Activity Tolerance
- Avoid unnecessary activities and stress that might precipitate a hypotensive episode.
- Detect signs of infection or presence of stressors that may have triggered the crisis.
- Explain the rationale for minimizing stress during acute crisis and increased activity.
Promoting Home, Community-Based, and Transitional Care
Educating Patients About Self-Care
- Provide patient and family explicit verbal and written instructions about the rationale for replacement therapy and proper dosage.
- Educate patient and family about how to modify drug dosage and increase salt intake in times of illness, very hot weather, and stressful situations.
- Modify diet and fluid intake to maintain fluid and electrolyte balance.
- Provide patient and family with preloaded, single-injection syringes of corticosteroid for use in emergencies and instruct them when and how to use.
- Advise patient to inform health care providers (e.g., dentists) of steroid use.
- Urge patient to wear a medical alert bracelet and to carry information at all times about the need for corticosteroids.
- Educate patient and family about the signs of excessive or insufficient hormone replacement.
Continuing and Transitional Care
- If patient cannot return to work and family responsibilities after hospital discharge, refer patient to home care to ensure a safe environment; assess patient's recovery; monitor hormone replacement; and evaluate stress in the home.
- Assess patient's and family's knowledge about medication regimen compliance; emphasize the side effects of medications and dietary modifications.
- Assess patient's plans for regular medical follow-up to clinic or health care provider's office.
- Encourage the patient to wear medical identification for Addison disease.
- Remind patient and family about the importance of health promotion activities and health screening.
Evaluation
Expected Patient Outcomes
- Decreases risk of injury
- Decreases risk of infection
- Increases participation in self-care activities
- Attains/maintains skin integrity
- Achieves improved body image
- Exhibits improved mental functioning
- Exhibits absence of complications
For more information, see Chapter 52 in Hinkle, J. L., & Cheever, K. H. (2018). Brunner and Suddarth's textbook of medical-surgical nursing (14th ed.). Philadelphia, PA: Lippincott Williams & Wilkins.
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