States Associated with Coagulation Factor Deficiencies
| Factor | Synonym(s) | States Associated with Deficiency Congenital | States Associated with Deficiency Acquired |
|---|---|---|---|
Extrinsic Pathway | |||
| II | Prothrombin | Hypoprothrombinemia | Vitamin K deficiency Liver disease |
| V | Accelerator globulin (AcG), proaccelerin, labile factor | Parahemophilia | Liver disease Acute leukemia Surgery |
| VII | Proconvertin, autoprothrombin I, serum prothrombin conversion accelerator (SPCA) | Factor VII deficiency | Liver disease Vitamin K deficiency Antibiotic therapy |
| X | Stuart factor, Stuart-Prower factor, autoprothrombin III | Stuart factor deficiency | Liver disease Vitamin K deficiency Anticoagulants Normal pregnancy Disseminated intravascular coagulation (DIC) Hemorrhagic disease of the newborn |
| Intrinsic Pathway | |||
| VIII* | Antihemophilic factor (AHF), antihemophilic globulin (AHG) | Hemophilia A (classic hemophilia) von Willebrand's disease | Disseminated intravascular coagulation (DIC) Fibrinolysis |
| IX | Christmas factor, antihemophilic factor B, plasma thromboplastin component (PTC), autoprothrombin II | Hemophilia B (Christmas disease) | Liver disease Vitamin K deficiency Anticoagulants Nephrotic syndrome |
| XI | Plasma thromboplastin antecedent (PTA) | Factor XI deficiency | Liver disease Vitamin K deficiency Anticoagulants Congenital heart disease |
| XII | Hageman factor | Hageman trait | Normal pregnancy Nephrotic syndrome |
| Common Pathway | |||
| XIII | Fibrin-stabilizing factor | Factor XIII deficiency | Liver disease Lead poisoning Multiple myeloma Agammaglobulinemia Elevated fibrinogen levels Postoperatively |
*Factor VIII is increased in normal pregnancy (as is factor X) and in states of inflammation and other physiologic stress.