Causes of Tissue Hypoxia that may Stimulate Erythropoietin Release
- Acute blood loss
- Impaired oxygen-carbon dioxide exchange in the lungs
- Low hemoglobin levels
- Impaired binding of oxygen to hemoglobin
- Impaired release of oxygen from hemoglobin
- Excessive hemolysis of erythrocytes due to hypersplenism or hemolytic disorders of antibody, bacterial, or chemical origin
- Certain anemias in which abnormal red blood cells are produced (e.g., hereditary spherocytosis)
- Compromised blood flow to the kidneys