Disorders and Drugs Associated with Altered Serum Calcium Levels

[Show Table Outline]

Increased Levels (Hypercalcemia)

Disorders

• Acidosis
• Hyperparathyroidism
• Cancers involving bone
• Paget's disease of bone
• Prolonged immobility
• Leukemia
• Multiple myeloma
• Lymphomas
• Hyperproteinemia
• Polycythemia vera
• Bone growth or active bone formation
• Vitamin D intoxication
• Hyperthyroidism (severe)
• Milk-alkali syndrome

Drugs

• Thiazide diuretics
• Hormones (androgens, progestins, estrogens)
• Vitamin D
• Calcium supplements

Decreased Levels (Hypocalcemia)

Disorders

• Alkalosis
• Hypoparathyroidism
• Pseudohypoparathyroidism
• Inadequate dietary intake of calcium and/or vitamin D
• Vitamin D-resistant rickets
• Malabsorption syndromes
• Hypoproteinemia
• Laxative abuse
• Acute pancreatitis
• Burns
• Osteomalacia
• Peritonitis
• Pregnancy
• Overwhelming infections
• Hypomagnesemia
• Renal failure
• Phosphate excess

Drugs

• Barbiturates
• Anticonvulsants
• Acetazolamide (Diamox)
• Adrenocorticosteroids
• Cytotoxic drugs

[Table Outline]

• Increased Levels (Hypercalcemia)
• Decreased Levels (Hypocalcemia)