Causes of Altered Serum Globulin Levels
| Globulin | Increased Levels | Decreased Levels |
|---|---|---|
 1 | Pregnancy - Malignancies - Acute infections - Tissue necrosis | Genetic deficiency of 1-antitrypsin |
| 2 | Acute infections | Hemolytic anemia |
| Trauma, burns | Severe liver disease | |
| Advanced malignancies | ||
| Rheumatic fever | ||
| Rheumatoid arthritis | ||
| Acute myocardial infarction | ||
| Nephrotic syndrome | ||
 | Hypothyroidism - Biliary cirrhosis - Nephrotic syndrome - Diabetes mellitus - Cushing's syndrome - Malignant hypertension | Hypocholesterolemia |
 | Connective tissue diseases (such as systemic lupus erythematosus and rheumatoid arthritis) | Nephrotic syndrome - Lymphocytic leukemia |
| Hodgkin's disease | Lymphosarcoma | |
| Chronic active liver disease | Drugs | |
| Drugs | Bacille Calmetté-Guérin vaccine | |
| Tolazamide (Tolinase) | ||
| Tubocurarine | Methotrexate | |
| Anticonvulsants |