Causes of Altered Erythrocyte Osmotic Fragility
Decreased Fragility |
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Iron-deficiency anemias |
Hereditary anemias (sickle cell, hemoglobin C, thalassemias) |
Liver diseases |
Polycythemia vera |
Splenectomy |
Obstructive jaundice |
Increased Fragility |
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Hereditary spherocytosis |
Hemolytic anemias |
Autoimmune anemias |
Burns |
Toxins (bacterial, chemical) |
Hypotonic infusions |
Transfusion with incompatible blood |
Mechanical trauma to RBCs (prosthetic heart valves, disseminated intravascular clotting, parasites) |
Enzyme deficiencies (PK kinase, G-6-PD) |