Summary of Autoantibody-Related Disorders and Tests Used in Diagnosis
| Antibody | Incidence Present in 90% or More of Cases | Incidence Present in 50-90% of Cases | Incidence Present in <50% of Cases |
|---|---|---|---|
C-reactive protein (CRP) | Rheumatic fever Rheumatoid arthritis Acute bacterial infections Viral hepatitis | Active tuberculosis Gout Advanced cancers Leprosy Cirrhosis Burns Peritonitis | Multiple sclerosis Guillain-Barré syndrome Scarlet fever Varicella Surgery Intrauterine contraceptive devices |
| Rheumatoid factor (RF) | Rheumatoid arthritis | Early rheumatoid arthritis SLE Scleroderma Dermatomyositis | Advanced age Juvenile rheumatoid arthritis (20%) Infectious diseases Healthy adults (<5%) |
| Antinuclear antibodies (ANA) | Systemic lupus erythematosus (SLE) | Sjögren's syndrome Scleroderma Drug-induced SLE-like syndrome Chronic active hepatitis Heart disease, with long-term procainamide therapy | Burns Asbestosis Juvenile chronic polyarthritis Rheumatoid arthritis Rheumatic fever Myasthenia gravis Advanced age Dermatomyositis Polyarteritis nodosa Primary biliary cirrhosis |
| Anti-DNA | Active SLE | SLE in remission | Juvenile rheumatoid arthritis Progressive systemic sclerosis Drug-induced SLE-like syndrome Uveitis |
| Cold agglutinins | Atypical pneumonia Influenza Pulmonary embolus | Viral infections Infectious mononucleosis Lymphoreticular malignancy | Congenital syphilis Malaria Anemia Cirrhosis |
| Lupus erythematosus (LE) cell preparation | SLE | – | – |
| Cryoglobulins | Raynaud's syndrome Cryoglobulinemia | – | – |
- C-reactive protein (CRP)
- Rheumatoid factor (RF)
- Antinuclear antibodies (ANA)
- Anti-DNA
- Cold agglutinins
- Lupus erythematosus (LE) cell preparation
- Cryoglobulins