Cell- and Tissue-Specific Antibodies
| Antibody Target Cell/Tissue | Diseases for Which the Test Is Usually Diagnostic | Other Diseases in Which This Antibody May Also Be Present |
|---|---|---|
| Skeletal muscle | Myasthenia gravis | |
| Cardiac muscle | Myocardial infarction | Acute rheumatic fever |
| Smooth muscle | Chronic active hepatitis | Biliary cirrhosis Viral hepatitis Infectious mononucleosis Systemic lupus erythematosus (SLE) (10%) |
| Mitochondria | Primary biliary cirrhosis Drug-induced jaundice | Chronic active hepatitis Viral hepatitis SLE (20%) |
| Skin | Pemphigus | – |
| Altered IgG | Rheumatoid arthritis | – |
| Adrenal cells | Addison's disease | – |
| Intrinsic factor, parietal cells | Pernicious anemia | SLE (5%) |
| Long-acting thyroid stimulator | Graves' disease Hashimoto's thyroiditis | – |
| Long-acting thyroid microsomes | Primary myxedema Juvenile lymphocytic thyroiditis Graves' disease Healthy adults | SLE (5%) Pernicious anemia (25%) Allergies |
| Thyroglobulin | Hashimoto's thyroiditis Primary myxedema Graves' disease | Pernicious anemia Allergies Healthy adults (5-10%) |
| Salivary ducts | Sjögren's syndrome | Rheumatoid arthritis |
| Red blood cell membrane | Autoimmune hemolytic anemia | Transfusion reaction |
| Platelet cell membrane | Idiopathic thrombocytopenic purpura | – |
| Basement membranes of lungs, renal glomeruli | Goodpasture's syndrome Glomerulonephritis | – |