Conditions Associated with Elevated Serum Alkaline Phosphatase Levels

[Show Table Outline]

Pronounced Elevation (5 or more times normal)

• Advanced pregnancy
• Biliary obstruction
• Biliary atresia
• Cirrhosis
• Osteitis deformans
• Osteogenic sarcoma
• Hyperparathyroidism (primary, or secondary to chronic renal disease)
• Paget's disease
• Infusion of albumin of placental origin

Moderate Elevation (3-5 times normal)

• Granulomatous or infiltrative liver diseases
• Infectious mononucleosis
• Metastatic tumors in bone
• Metabolic bone diseases (rickets, osteomalacia)
• Extrahepatic duct obstruction

Mild Elevation (up to 3 times normal)

• Viral hepatitis
• Chronic active hepatitis
• Cirrhosis (alcoholic)
• Healing fractures
• Early pregnancy
• Growing children
• Large doses of vitamin D
• Congestive heart failure

[Table Outline]

• Pronounced Elevation (5 or more times normal)
• Moderate Elevation (3-5 times normal)
• Mild Elevation (up to 3 times normal)