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1Scott RA, Bridgewater SG, Ashton HA. Randomized clinical trial of screening for abdominal aortic aneurysm in women. Br J Surg. 2002;89(3):283-285.

1Eckel R, et al. Statin toxicity: mechanistic insights and clinical implications. Circ Res. 2019;124:328-350.

1This includes women with prior pregnancy complications including hypertensive disorders of pregnancy, gestational diabetes, preterm birth, stillbirth, LBW infant, or placental abruption.

1Use Pooled Cohort Equations to replace Framingham Risk Score. Pooled Cohort Equations incorporate age, sex, race, total cholesterol, HDL cholesterol, systolic BP, use of antihypertensive medication, and history of diabetes and/or tobacco use.

2HeartScore Europe incorporates age, sex, systolic BP, total cholesterol, HDL cholesterol, and history of tobacco use.

1Eye, ear, laparoscopy, cystoscopy, and arthroscopic operations.

2Prior VTE, cancer, stroke, obesity, congestive heart failure pregnancy, thrombophilic medications (tamoxifen, raloxifene, lenalidomide, thalidomide, erythroid-stimulating agents).

1Selected factors in the rising risk of major bleeding complications:

General risk factors: active bleeding, previous major bleed, known untreated bleeding disorder, renal or liver failure, thrombocytopenia, acute stroke, uncontrolled high BP, concomitant use of anticoagulants, or antiplatelet therapy.

Procedure-specific risk factors: major abdominal surgery—extensive cancer surgery, pancreatic-duodenectomy, hepatic resection, cardiac surgery, thoracic surgery (pneumonectomy or extended resection). Procedures where bleeding complications have especially severe consequences: craniotomy, spinal surgery, spinal trauma.