Antifolate Medications, Oncologic Use, and Differences in Structures as Compared to Folic Acid
| Folic Acid |  | ||
|---|---|---|---|
| DRUG | TARGET | COMMON ONCOLOGIC USES | CHEMICAL STRUCTURE |
| Methotrexate (MTX) | DHFR | High dose: ALL, NHL, osteosarcoma Low dose: various; including breast, CTCL, ALL maintenance, etc. |  |
| Pemetrexed (PMX) | DHFR, TS, GARFT, AIRCARFT | Nonsquamous NSCLC, mesothelioma |  |
| Pralatrexate (PDX) | DHFR | PTCL |  |
AIRCARFT, aminoimidazole carboxamide ribonucleotide formyltransferase; ALL, acute lymphocytic leukemia; CTCL, cutaneous T-cell lymphoma; DHFR, dihydrofolate reductase; GARFT, glycinamide ribonucleotide formyltransferase; MTX, methotrexate; NHL, non-Hodgkin lymphoma; NSCLC, non-small cell lung cancer; PTCL, peripheral T-cell lymphoma; TS, thymidylate synthase.