7.Which one of the following sequential chemotherapy administrations does NOT increase the efficacy of the regimen by synergism between the chemotherapeutic components of each regimen?

A. High-dose methotrexate before high-dose cytarabine in even courses of hyperCVAD regimen

B. Cytarabine starting 2 hours after cladribine in CLAG-M

C. Cytarabine 4 hours after fludarabine in FLAG-Ida

D. Asparaginase after methotrexate in pediatric-inspired protocol for treatment of ALL

E. Oxaliplatin before 5-FU (bolus and continuous) in FOLFOX