3.A previously healthy 37-year-old man presented with leukocytosis and peripheral blasts. He was diagnosed with AML with normal karyotype. Mutational analysis revealed FLT3-ITD mutation with 32% allelic burden. He underwent 7 + 3 with midostaurin induction therapy. Upon count recovery, a repeat bone marrow biopsy and aspiration showed refractory leukemia and a repeat mutational analysis confirmed persistence of FLT3-ITD mutation. How would you treat him?

A. Reinduction with 7 + 3 chemotherapy

B. Midostaurin single agent

C. Allogeneic stem cell transplantation

D. Gilteritinib