1.A 44-year-old woman with leukocytosis/lymphocytosis and cervical lymphadenopathy (LAD) was diagnosed with chronic lymphocytic leukemia (CLL). Her CLL has 13q deletion and mutated immunoglobulin heavy-chain gene rearrangement CLL. She received six cycles of FCR (fludarabine, cyclophosphamide, and rituximab) and achieved complete remission with complete resolution of lymphadenopathy and splenomegaly along with normalization of WBC and platelet counts. However, the patient reports severe fatigue and mild dyspnea on exertion. CBC shows hemoglobin of 4.8 g/dL. What is the most likely reason for her profound anemia?

A. Autoimmune hemolytic anemia

B. Minimal residual disease in bone marrow

C. Fludarabine-induced GI microperforation

D. Cyclophosphamide-induced myelodysplasia

E. Rituximab-induced hemagglutination