3.A 56-year-old woman with glioblastoma multiforme (GBM) is started on temozolomide with concurrent brain radiation therapy. She is informed by her oncologist that increased efficacy with temozolomide is seen in patients with GBM with a certain mutational status owing to reduced ability for those cancer cells to have sufficient cellular repair. What is this mutational status?

A. Wild-type IDH1

B. 1p/19q Co-deletion

C. MGMT promotor methylation

D. NPM1 mutated

E. FLT3-ITD