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Information

Neoadjuvant Therapy

Combination Regimens

ACT

Doxorubicin:

60 mg/m2 IV on day 1

Cyclophosphamide:

600 mg/m2 IV on day 1

Docetaxel:

100 mg/m2 IV on day 1

Repeat cycle every 21 days for a total of 4 cycles, followed by surgery [80].

Docetaxel + Carboplatin + Pertuzumab + Trastuzumab

Docetaxel:

75 mg/m2 IV on day 1

Carboplatin:

AUC 6, IV on day 1

Pertuzumab:

840 mg IV loading dose on day 1 and then 420 mg IV every 3 weeks

Trastuzumab:

8 mg/kg IV loading dose on day 1 and then 6 mg/kg IV every 3 weeks

Repeat cycle every 21 days [81].

Adjuvant Therapy

Combination Regimens: HER2-negative disease

AC

Doxorubicin:

60 mg/m2 IV on day 1

Cyclophosphamide:

600 mg/m2 IV on day 1

Repeat cycle every 21 days for a total of 4 cycles [82].

ACT

Doxorubicin:

60 mg/m2 IV on day 1

Cyclophosphamide:

600 mg/m2 IV on day 1

Repeat cycle every 21 days for a total of 4 cycles, followed by

Paclitaxel:

175 mg/m2 IV on day 1

Repeat cycle every 21 days for a total of 4 cycles [83].

ACT (weekly)

Doxorubicin:

60 mg/m2 IV on day 1

Cyclophosphamide:

600 mg/m2 IV on day 1

Repeat cycle every 21 days for a total of 4 cycles, followed by

Paclitaxel:

80 mg/m2 IV on day 1

Repeat on a weekly schedule for 12 weeks [84].

ACDocetaxel

Doxorubicin:

60 mg/m2 IV on day 1

Cyclophosphamide:

600 mg/m2 IV on day 1

Repeat cycle every 21 days for a total of 4 cycles, followed by

Paclitaxel:

100 mg/m2 IV on day 1

Repeat cycle every 21 days for a total of 4 cycles [85].

ACDocetaxel (weekly)

Doxorubicin:

60 mg/m2 IV on day 1

Cyclophosphamide:

600 mg/m2 IV on day 1

Repeat cycle every 21 days for a total of 4 cycles, followed by

Docetaxel:

35 mg/m2 IV on day

Repeat weekly for a total of 12 weeks [86].

TC

Docetaxel:

75 mg/m2 IV on day 1

Cyclophosphamide:

600 mg/m2 IV on day 1

Repeat cycle every 21 days for a total of 4 cycles [87].

TAC

Docetaxel:

75 mg/m2 IV on day 1

Doxorubicin:

50 mg/m2 IV on day 1

Cyclophosphamide:

500 mg/m2 IV on day 1

Repeat cycle every 21 days for a total of 6 cycles [88].

CAF

Cyclophosphamide:

600 mg/m2 IV on day 1

Doxorubicin:

60 mg/m2 IV on day 1

5-Fluorouracil:

600 mg/m2 IV on day 1

Repeat cycle every 28 days for a total of 4 cycles [89].

Epirubicin + CMF

Epirubicin:

100 mg/m2 IV on day 1

Repeat cycle every 21 days for 4 cycles, followed by

Cyclophosphamide:

600 mg/m2 IV on day 1

Methotrexate:

40 mg/m2 IV on day 1

5-Fluorouracil:

600 mg/m2 IV on day 1

Repeat cycle every 21 days for a total of 4 cycles [90].

FEC

5-Fluorouracil:

500 mg/m2 IV on day 1

Epirubicin:

100 mg/m2 IV on day 1

Cyclophosphamide:

500 mg/m2 IV on day 1

Repeat cycle every 21 days for a total of 6 cycles [91].

FECDocetaxel

5-Fluorouracil:

500 mg/m2 IV on day 1

Epirubicin:

100 mg/m2 IV on day 1

Cyclophosphamide:

500 mg/m2 IV on day 1

Repeat cycle every 21 days for a total of 6 cycles [92], followed by

Docetaxel:

100 mg/m2 IV on day 1

Repeat cycle every 21 days for 3 cycles.

Dose-Dense Combination Regimens: HER2-negative disease

ACT

Doxorubicin:

60 mg/m2 IV on day 1

Cyclophosphamide:

600 mg/m2 IV on day 1

Repeat cycle every 14 days for a total of 4 cycles, followed by

Paclitaxel:

175 mg/m2 IV on day 1

Repeat cycle every 14 days for a total of 4 cycles [93].

Administer pegfilgrastim 6 mg SC on day 2 of each treatment cycle.

ATC

Doxorubicin:

60 mg/m2 IV on day 1

Repeat cycle every 2 weeks for 4 cycles, followed by

Paclitaxel:

175 mg/m2 IV on day 1

Repeat cycle every 2 weeks for 4 cycles, followed by

Cyclophosphamide:

600 mg/m2 IV on day 1

Repeat cycle every 2 weeks for 4 cycles.

Administer filgrastim 5 μg/kg SC on days 3-10 of each treatment cycle [94].

ACDocetaxel

Doxorubicin:

60 mg/m2 IV on day 1

Cyclophosphamide:

600 mg/m2 IV on day 1

Repeat cycle every 14 days for a total of 4 cycles, followed by

Cyclophosphamide:

75 mg/m2 IV on day 1

Repeat cycle every 14 days for a total of 4 cycles [95].

Administer pegfilgrastim 6 mg SC on day 2 of each treatment cycle.

DocetaxelAC

Docetaxel:

75 mg/m2 IV on day 1

Repeat cycle every 14 days for a total of 4 cycles, followed by

Doxorubicin:

60 mg/m2 IV on day 1

Cyclophosphamide:

600 mg/m2 IV on day 1

Repeat cycle every 14 days for a total of 4 cycles [95].

Administer pegfilgrastim 6 mg SC on day 2 of each treatment cycle.

Combination Regimens: HER2-positive disease

ACT + Trastuzumab

Doxorubicin:

60 mg/m2 IV on day 1

Cyclophosphamide:

600 mg/m2 IV on day 1

Repeat cycle every 21 days for a total of 4 cycles, followed by

Paclitaxel:

80 mg/m2 IV over 1 hour on day 1

Trastuzumab:

4 mg/kg IV loading dose, then 2 mg/kg IV weekly

Repeat weekly for 12 weeks, followed by

Trastuzumab:

2 mg/kg IV weekly

Repeat weekly for 40 weeks [96].

ACT + Trastuzumab (dose-dense)

Doxorubicin:

60 mg/m2 IV on day 1

Cyclophosphamide:

600 mg/m2 IV on day 1

Repeat cycle every 14 days for a total of 4 cycles, followed by

Paclitaxel:

175 mg/m2 IV on day 1

Repeat cycle every 14 days for a total of 4 cycles.

Trastuzumab:

4 mg/kg IV loading dose along with paclitaxel and then 2 mg/kg IV weekly

Trastuzumab is administered for a total of 1 year [97].

TCH

Docetaxel:

75 mg/m2 IV on day 1

Carboplatin:

AUC of 6, IV on day 1

Trastuzumab:

4 mg/kg IV loading dose and then 2 mg/kg IV weekly

Repeat chemotherapy every 21 days for a total of 6 cycles. At the completion of chemotherapy, trastuzumab is administered at 6 mg/kg IV every 3 weeks for a total of 1 year [98].

DHFEC

Docetaxel:

100 mg/m2 IV on day 1

Trastuzumab

4 mg/kg IV loading dose on day 1 and then 2 mg/kg IV weekly

Repeat cycle every 21 days for 3 cycles, followed by

5-Fluorouracil:

600 mg/m2 IV on day 1

Epirubicin:

60 mg/m2 IV on day 1

Cyclophosphamide:

600 mg/m2 IV on day 1

Repeat cycle every 21 days for 3 cycles [99].

Pertuzumab + Trastuzumab + Docetaxel

Docetaxel:

75 mg/m2 IV on day 1

Trastuzumab:

8 mg/kg IV loading dose on day 1 and then 6 mg/kg IV every 3 weeks

Pertuzumab:

840 mg IV loading dose on day 1 and then 420 mg IV every 3 weeks

Repeat cycle every 21 days [100].

Single-Agent Regimens

Neratinib

Neratinib:

240 mg PO daily

Repeat daily for 1 year in patients following trastuzumab-based adjuvant therapy [101].

Ado-trastuzumab emtansine

Ado-trastuzumab emtansine:

3.6 mg/kg IV on day 1

Repeat cycle every 21 days for a total of 14 cycles [102].

Hormonal Regimens

Tamoxifen

Tamoxifen:

20 mg PO daily

Repeat daily for 5 years in patients with ER+ tumors or ER status unknown [103].

Anastrozole

Anastrozole:

1 mg PO daily

Repeat daily for 5 years in patients with ER+ tumors or ER status unknown [104].

Letrozole

Letrozole:

2.5 mg PO daily

Repeat daily for 5 years in patients with ER+ or PR+ tumors [105].

Tamoxifen + Letrozole [106]

Tamoxifen:

20 mg PO daily for 5 years, followed by

Letrozole:

2.5 mg PO daily for 5 years

Tamoxifen + Exemestane [107]

Tamoxifen:

20 mg PO daily for 2-3 years, followed by

Exemestane:

25 mg PO daily for the remainder of 5 years

Tamoxifen + Goserelin + Zoledronic acid

Tamoxifen:

20 mg PO daily

Goserelin:

3.6 mg SC every 28 days

Zoledronic acid

4 mg IV every 6 months

Continue treatment for a total of 3 years [108].

Anastrozole + Goserelin + Zoledronic acid

Anastrozole:

1 mg PO daily

Gosrelin:

3.6 mg SC every 28 days

Zoledronic acid

4 mg IV every 6 months

Continue treatment for a total of 3 years [108].

Olaparib

Olaparib:

300 mg PO bid daily

Repeat cycle every 24 days and continue treatment for 12 months [109].

Abemaciclib + Tamoxifen

Abemaciclib:

150 mg PO bid for 2 years

Tamoxifen:

20 mg PO daily for 5 years

Continue treatment with abemaciclib for 2 years and with tamoxifen for 5 years [110].

Abemaciclib + Aromatase Inhibitor

Abemaciclib:

150 mg PO bid for 2 years

Aromatase Inhibitor:

PO daily for five years

Continue treatment with abemaciclib for 2 years and with aromatase inhibitor for 5 years [111].

Everolimus + Exemestane [112]

Everolimus:

10 mg PO daily

Exemestane:

25 mg PO daily

Metastatic Disease

Combination Regimens: HER2-negative disease

AC

Doxorubicin:

60 mg/m2 IV on day 1

Cyclophosphamide:

600 mg/m2 IV on day 1

Repeat cycle every 21 days [82].

AT

Doxorubicin:

50 mg/m2 IV on day 1

Paclitaxel:

150 mg/m2 IV over 24 hours on day 1

Repeat cycle every 21 days [113].

or

Doxorubicin:

60 mg/m2 IV on day 1

Repeat cycle every 21 days up to a maximum of 8 cycles, followed by

Paclitaxel:

175 mg/m2 IV on day 1

Repeat cycle every 21 days until disease progression [113].

or

Paclitaxel:

175 mg/m2 IV on day 1

Repeat cycle every 21 days until disease progression, followed by

Doxorubicin:

60 mg/m2 IV on day 1

Repeat cycle every 21 days up to a maximum of 8 cycles [113].

CAF

Cyclophosphamide:

600 mg/m2 IV on day 1

Doxorubicin:

60 mg/m2 IV on day 1

5-Fluorouracil:

600 mg/m2 IV on day 1

Repeat cycle every 21 days [89].

CEF

Cyclophosphamide:

75 mg/m2 PO on days 1-14

Epirubicin:

60 mg/m2 IV on days 1 and 8

5-Fluorouracil:

500 mg/m2 IV on days 1 and 8

Repeat cycle every 28 days [114].

CMF

Cyclophosphamide:

600 mg/m2 IV on day 1

Methotrexate:

40 mg/m2 IV on day 1

5-Fluorouracil:

600 mg/m2 IV on day 1

Repeat cycle every 21 days [90].

Capecitabine + Docetaxel (XT)

Capecitabine:

1,250 mg/m2 PO bid on days 1-14

Docetaxel:

75 mg/m2 IV on day 1

Repeat cycle every 21 days [115]. May decrease dose of capecitabine to 825-1,000 mg/m2 PO bid on days 1-14 to reduce the risk of toxicity without compromising clinical efficacy.

Capecitabine + Paclitaxel (XP)

Capecitabine:

825 mg/m2 PO bid on days 1-14

Paclitaxel:

175 mg/m2 IV on day 1

Repeat cycle every 21 days [116].

Capecitabine + Navelbine (XN)

Capecitabine:

1,000 mg/m2 PO bid on days 1-14

Navelbine:

25 mg/m2 IV on days 1 and 8

Repeat cycle every 21 days [116].

Capecitabine + Ixabepilone (XI)

Capecitabine:

1,000 mg/m2 PO bid on days 1-14

Ixabepilone:

40 mg/m2 IV on day 1

Repeat cycle every 21 days [117].

Docetaxel + Doxorubicin

Docetaxel:

75 mg/m2 IV on day 1

Doxorubicin:

50 mg/m2 IV on day 1

Repeat cycle every 21 days [118].

Doxorubicin liposome + Docetaxel

Doxorubicin liposome:

30 mg/m2 on day 1

Docetaxel:

60 mg/m2 on day 1

Repeat cycle every 21 days [119].

FEC-100

5-Fluorouracil:

500 mg/m2 IV on day 1

Epirubicin:

100 mg/m2 IV on day 1

Cyclophosphamide:

500 mg/m2 IV on day 1

Repeat cycle every 21 days [120].

FEC-75

5-Fluorouracil:

500 mg/m2 IV on day 1

Epirubicin:

75 mg/m2 IV on day 1

Cyclophosphamide:

500 mg/m2 IV on day 1

Repeat cycle every 21 days [121].

FEC-50

5-Fluorouracil:

500 mg/m2 IV on day 1

Epirubicin:

50 mg/m2 IV on day 1

Cyclophosphamide:

500 mg/m2 IV on day 1

Repeat cycle every 21 days [121].

Gemcitabine + Paclitaxel

Gemcitabine:

1,250 mg/m2 IV on days 1 and 8

Paclitaxel:

175 mg/m2 IV on day 1

Repeat cycle every 21 days [122].

Carboplatin + Paclitaxel

Carboplatin:

AUC of 6, IV on day 1

Paclitaxel:

200 mg/m2 IV over 3 hours on day 1

Repeat cycle every 21 days [123].

Carboplatin + Docetaxel

Carboplatin:

AUC of 6, IV day on 1

Docetaxel:

75 mg/m2 IV on day 1

Repeat cycle every 21 days [124].

Paclitaxel + Bevacizumab

Paclitaxel:

90 mg/m2 IV on days 1, 8, and 15

Bevacizumab:

10 mg/kg on days 1 and 15

Repeat cycle every 28 days [125].

Atezolizumab + Nab-Paclitaxel

Atezolizumab:

840 mg IV on days 1 and 15

Nab-Paclitaxel:

100 mg/m2 IV on days 1, 8, and 15

Repeat cycle every 28 days [126].

Combination Regimens: HER2-positive disease

Pertuzumab + Trastuzumab + Docetaxel

Pertuzumab:

840 mg IV loading dose on day 1 and then 420 mg IV every 3 weeks

Trastuzumab:

8 mg/kg IV loading dose on day 1 and then 6 mg/kg IV every 3 weeks

Docetaxel:

75 mg/m2 IV on day 1

Repeat cycle every 21 days [100].

Trastuzumab + Paclitaxel

Trastuzumab:

4 mg/kg IV loading dose and then 2 mg/kg weekly

Paclitaxel:

175 mg/m2 IV over 3 hours on day 1

Repeat cycle every 21 days [127].

or

Trastuzumab:

4 mg/kg IV loading dose and then 2 mg/kg weekly

Paclitaxel:

80 mg/m2 IV weekly

Repeat cycle every 4 weeks [128].

Trastuzumab + Docetaxel

Trastuzumab:

4 mg/kg IV loading dose and then 2 mg/kg IV on days 8 and 15

Docetaxel:

35 mg/m2 IV on days 1, 8, and 15

First cycle is administered weekly for 3 weeks, with 1 week of rest. For subsequent cycles,

Trastuzumab:

2 mg/kg IV weekly

Docetaxel:

35 mg/m2 IV weekly

Repeat cycle every 4 weeks [129].

TCH

Carboplatin:

AUC of 6, IV on day 1

Docetaxel:

75 mg/m2 IV on day 1

Trastuzumab:

4 mg/kg IV loading dose on day 1 and then 2 mg/kg IV on days 8 and 15, 2 mg/kg IV weekly thereafter

Repeat cycle every 21 days [130].

Gemcitabine + Carboplatin + Trastuzumab

Gemcitabine:

1,500 mg/m2 IV on day 1

Carboplatin:

AUC of 2.5, IV on day 1

Trastuzumab:

8 mg/kg IV loading dose on day 1 and then 4 mg/kg IV every 2 weeks

Repeat cycle every 2 weeks [131].

Trastuzumab + Navelbine

Trastuzumab:

4 mg/kg IV loading dose and then 2 mg/kg IV weekly

Navelbine:

25 mg/m2 IV weekly

Repeat on a weekly basis until disease progression [132].

Trastuzumab + Gemcitabine

Trastuzumab:

4 mg/kg IV loading dose and then 2 mg/kg IV weekly

Gemcitabine:

1,200 mg/m2 IV weekly for 2 weeks

Repeat cycle every 21 days [133].

Trastuzumab + Capecitabine

Trastuzumab:

4 mg/kg IV loading dose and then 2 mg/kg IV weekly

Capecitabine:

1,250 mg/m2 PO bid on days 1-14

Repeat cycle every 21 days [134].

or

Trastuzumab:

8 mg/kg IV loading dose and then 6 mg/kg IV on day 1 of all subsequent cycles

Capecitabine:

1,250 mg/m2 PO bid on days 1-14

Repeat cycle every 21 days [135].

Trastuzumab + Lapatinib

Trastuzumab:

4 mg/kg IV loading dose and then 2 mg/kg IV weekly

Lapatinib:

1,000 mg PO daily

Continue until disease progression [136].

Capecitabine + Lapatinib

Capecitabine:

1,000 mg/m2 PO bid on days 1-14

Lapatinib:

1,250 mg PO daily

Repeat cycle every 21 days [137].

Capecitabine + Neratinib

Capecitabine:

750 mg/m2 PO bid on days 1-14

Neratinib:

240 mg PO daily

Repeat cycle every 21 days [138].

Tucatinib + Trastuzumab + Capecitabine

Tucatinib:

300 mg PO bid

Trastuzumab:

8 mg/kg IV loading dose followed by 6 mg/kg IV on day 1

Capecitabine:

1,000 mg/m2 PO bid on days 1-21

Repeat cycle every 21 days [139].

Margetuximab-cmkb + Capecitabine

Margetuximab:

15 mg/kg IV on day 1

Capecitabine:

1,000 mg/m2 PO bid on days 1-14

Repeat cycle every 21 days [140].

Margetuximab-cmkb + Eribulin

Margetuximab:

15 mg/kg IV on day 1

Eribulin:

1.4 mg/m2 IV on days 1 and 8

Repeat cycle every 21 days [140].

Margetuximab-cmkb + Vinorelbine

Margetuximab:

15 mg/kg IV on day 1

Vinorelbine:

25 mg/m2 IV on days 1 and 8

Repeat cycle every 21 days [140].

Margetuximab-cmkb + Gemcitabine

Margetuximab:

15 mg/kg IV on day 1

Gemcitabine:

1,000 mg IV on days 1 and 8

Repeat cycle every 21 days [140].

Combination Regimens: Hormone-Receptor Positive, HER2-Negative Disease

Everolimus + Exemestane [112]

Everolimus:

10 mg PO daily

Exemestane:

25 mg PO daily

Palbociclib + Letrozole

Palbociclib:

125 mg PO daily for 21 days

Letrozole:

2.5 mg PO daily

Repeat cycle every 21 days [141].

Ribociclib + Letrozole

Ribociclib:

600 mg PO daily for 21 days

Letrozole:

2.5 mg PO daily

Repeat cycle every 28 days [142].

Palbociclib + Fulvestrant

Palbociclib:

125 mg PO daily for 21 days

Fulvestrant:

500 mg IM on days 1 and 15 of first cycle and then 500 mg IM on day 1 for all subsequent cycles

Repeat cycle every 28 days [143].

Abemaciclib + Fulvestrant

Abemaciclib:

150 mg PO bid

Fulvestrant:

500 mg IM on days 1 and 15 of first cycle and then 500 mg IM on day 1 for all subsequent cycles

Repeat cycle every 28 days [144].

Alpelisib + Fulvestrant

Alpelisib:

300 mg PO daily

Fulvestrant:

500 mg IM on days 1, 15, and 29 and then once per month

Repeat cycle every 28 days [145].

Abemaciclib + Anastrozole

Abemaciclib:

150 mg PO bid

Anastrozole:

1 mg PO daily

Repeat cycle every 28 days [146].

Abemaciclib + Letrozole

Abemaciclib:

150 mg PO bid

Letrozole:

2.5 mg PO daily

Repeat cycle every 28 days [146].

Single-Agent Regimens: Hormone-Receptor Positive and HER2-Positive Disease

Tamoxifen

Tamoxifen:

20 mg PO daily [147]

Toremifene

Toremifene:

60 mg PO daily [148]

Exemestane

Exemestane:

25 mg PO daily [149]

Anastrozole

Anastrozole:

1 mg PO daily [150]

Letrozole

Letrozole:

2.5 mg PO daily [151]

Fulvestrant

Fulvestrant:

250 mg IM on day 1

Repeat injection every month [152].

or

Fulvestrant:

500 mg IM loading dose on day 1, then 500 mg IM on days 15 and 29

Continue treatment on a monthly basis until disease progression [153].

Elacestrant (ESR1 mutation)

Elacestrant:

345 mg PO daily

Repeat cycle every 28 days until disease progression [154].

Megestrol

Megestrol:

40 mg PO qid [155]

Trastuzumab

Trastuzumab:

4 mg/kg IV loading dose and then 2 mg/kg IV weekly

Repeat cycle weekly for a total of 10 weeks. In the absence of disease progression, continue weekly maintenance dose of 2 mg/kg [156].

or

Trastuzumab:

8 mg/kg IV loading dose, then 6 mg/kg IV every 3 weeks

Continue treatment until disease progression [157].

Margetuximab

Margetuximab:

15 mg/kg IV on day 1

Repeat cycle every 21 days [158].

Trastuzumab and hyaluronidase

Trastuzumab and hyaluronidase:

600 mg trastuzumab SC and 10,000 units hyaluronidase SC on day 1

Repeat cycle every 21 days [159].

Ado-trastuzumab emtansine

Ado-trastuzumab:

3.6 mg/kg IV on day 1

Repeat cycle every 21 days [160].

Trastuzumab deruxtecan-nxki

Trastuzumab deruxtecan:

5.4 mg/kg IV on day 1

Repeat cycle every 21 days [161].

Capecitabine

Capecitabine:

1,250 mg/m2 PO bid on days 1-14

Repeat cycle every 21 days [162]. May decrease dose to 850-1,000 mg/m2 PO bid on days 1-14 to reduce risk of toxicity without compromising clinical efficacy.

Docetaxel

Docetaxel:

100 mg/m2 IV on day 1

Repeat cycle every 21 days [163].

or

Docetaxel:

35-40 mg/m2 IV weekly for 6 weeks

Repeat cycle every 8 weeks [164].

Paclitaxel

Paclitaxel:

175 mg/m2 IV over 3 hours on day 1

Repeat cycle every 21 days [165].

or

Paclitaxel:

80-100 mg/m2 IV weekly for 3 weeks

Repeat cycle every 4 weeks [166].

Ixabepilone

Ixabepilone:

40 mg/m2 IV on day 1

Repeat cycle every 21 days [167].

Vinorelbine

Vinorelbine:

30 mg/m2 IV on day 1

Repeat cycle every 7 days [168].

Doxorubicin

Doxorubicin:

20 mg/m2 IV on day 1

Repeat cycle every 7 days [169].

Gemcitabine

Gemcitabine:

725 mg/m2 IV weekly for 3 weeks

Repeat cycle every 28 days [170].

Doxorubicin liposome

Doxorubicin liposome:

40 mg/m2 IV on day 1

Repeat cycle every 28 days [171].

Abraxane

Abraxane:

260 mg/m2 IV on day 1

Repeat cycle every 21 days [172].

or

Abraxane:

125 mg/m2 IV on days 1, 8, and 15

Repeat cycle every 28 days [173].

Eribulin

Eribulin:

1.4 mg/m2 IV on days 1 and 8

Repeat cycle every 21 days [174].

Olaparib

Olapraib:

300 mg PO bid

Repeat cycle every 28 days [175].

Talazoparib

Talazoparib:

1 mg PO daily

Repeat cycle every 28 days [176].

Sacituzumab govitecan-hziy

Sacituzumab govitecan:

10 mg/kg IV on days 1 and 8

Repeat cycle every 21 days [177].

Single-Agent Regimens: Hormone-Receptor Positive and HER2-Negative Disease

Abemaciclib

Abemaciclib:

150 mg PO bid

Repeat cycle every 28 days [178].