Risk Assessment for Early-Onset Group B Streptococcal Disease Among Infants Born at >=35 Weeks of Gestation

Risk Assessment for Early-Onset Group B Streptococcal Disease Among Infants Born at >=35 Weeks of Gestation Streptococcal & Staphylococcal Infections

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Enhanced Observation

Neonatal Early-Onset Sepsis Calculator

Categorical Risk Assessment

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Blood cultures^a
Empiric antibiotics

Signs of clinical illness

Blood cultures^a
Empiric antibiotics

Maternal intrapartum temperature ≥38°C (100.4°F)

Routine newborn care

GBS IAP indicated for mother?

Routine newborn care

Clinical observation for 36-48 hours after birth

Blood cultures^a
Empiric antibiotics

Signs of clinical illness

Serial physical examination and vital signs for 36–48 hours
Blood culturesa and empiric antibiotics if infant develops signs of clinical illness

Routine newborn care

Maternal intrapartum temperature ≥38°C (100.4°F) or inadequate indicated GBS IAP?

^a Consider lumbar puncture and cerebrospinal fluid culture before initiation of empiric antibiotics for infants who are at the highest risk of infection, especially those with critical illness. Lumbar puncture should not be performed if the infant’s clinical condition would be compromised, and antibiotics should be administered promptly and not deferred because of procedure delays.

^b Adequate GBS IAP is defined as the administration of penicillin G, ampicillin, or cefazolin ≥4 hours before delivery.

Adequate GBS IAP^b given?