| Drug and Dosage | Use | Action | Assessment: Side Effects |
|---|
| Chlorpromazine (Thorazine)—preop IM 12.5–25.0 gm 1–2 hr before; IV 25–50 mg; PO 10–25 mg q4–6h; IM 25–50 mg q3–4h; suppository 50–100 mg q6–8h | Nausea, vomiting, hiccups, preoperative sedation, psychoses | Alters the effects of dopamine in the CNS; anticholinergic, alpha-adrenergic blocking | Sedation, extrapyramidal reactions; dry eyes, blurred vision; hypotension; constipation, dry mouth; photosensitivity |
 NURSING IMPLICATIONS: Keep flat 30 min after IM; change positions slowly; frequent mouth care; may turn urine pink to red-brown |
| Prochlorperazine dimaleate (Compazine)—PO, IM, rectal 5–30 mg 4 times daily | Nausea, vomiting, and retching | See Trimethobenzamide HCl | Drowsiness, orthostatic hypotension, palpitations, blurred vision, diplopia, headache |
| NURSING IMPLICATIONS: Use cautiously in children, women who are pregnant, and clients with liver disease |
| Trimethobenzamide HCl (Tigan)—PO, IM, rectal 250 mg 4 times daily | Nausea; vomiting | Suppresses chemoreceptors in the trigger zone located in the medulla oblongata | Drowsiness, vertigo; diarrhea, headache, hypotension; jaundice; blurred vision; rigid muscles |
| NURSING IMPLICATIONS: Give deep IM to prevent escape of solution; can cause edema, pain, and burning |