Dose-Response Relationships and Pharmacodynamic Parameters for Nondepolarizing Neuromuscular Blocking Drugs in Human Subjectsa

Dose-Response Relationships and Pharmacodynamic Parameters for Nondepolarizing Neuromuscular Blocking Drugs in Human Subjects^a

	ED₅₀ (mg/kg)	ED₉₅ (mg/kg)	CE₅₀ (ng/mL)	K_e0 (min^-1)	Intubating Dose (mg/kg)	Maximum Block (%)	Time to Maximum Block (min)	Clinical Duration of Response^b (min)
Long-acting
d-Tubocurarine	0.23	0.48	370	0.13	0.6	97	5.7	81
Pancuronium	0.036	0.067	88	—	0.08	100	2.9	86
Intermediate-acting
Rocuronium	0.147	0.305	3510	0.405	0.6	100	1.7	36
Vecuronium	0.027	0.043	92	0.17	0.1	100	2.4	44
Atracurium	0.12	0.21	449	0.13	0.5	100	3.2	46
Cisatracurium	0.026	0.04	126-158	0.07-0.09	0.1	100	5.2	45
Short-acting
Mivacurium	0.039	0.067	79.9	0.18	0.15	100	3.3	16.8

^a Derived using simultaneous pharmacokinetic/pharmacodynamic modeling.

^b Time from injection of the intubating dose to recovery of twitch to 25% of control.