Hepatic Damage May Occur in the Rat Model after Administration of Inhaled or Injected Drugs When the Inhaled Oxygen Concentration is 10% Conversely, Hepatic Damage Occurs after Administration of Halothane, but Not Enflurane or Isoflurane, When the Inhaled Concentration of Oxygen is 12% or 14%.

(From Shingu K, Eger EI, Johnson BH, et al. Effect of oxygen concentration, hyperthermia, and choice of vendor on anesthetic-induced hepatic injury in rats. Anesth Analg. 1983;62:146-150, with permission.)

Hepatic damage may occur in the rat model after administration of inhaled or injected drugs when the inhaled oxygen concentration is 10%. Conversely, hepatic damage occurs after administration of halothane, but not enflurane or isoflurane, when the inhaled concentration of oxygen is 12% or 14%.