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Table 19-4

Possible Explanations for Cardioprotective Effects Produced by Perioperative -Adrenergic Receptor Blockade

  • Decreased myocardial oxygen consumption and demand

  • Less stress on potentially ischemic myocardium owing to decreased heart rate and myocardial contractility

  • Attenuation of effects of endogenous catecholamines

  • Redistribution of coronary blood flow to ischemic areas

  • Increased coronary blood flow owing to increased diastolic time

  • Plaque stabilization owing to decrease in shear forces

  • Cardiac antidysrhythmic effects

  • Antiinflammatory effects (?)