Possible Explanations for Cardioprotective Effects Produced by Perioperative -Adrenergic Receptor Blockade
Decreased myocardial oxygen consumption and demand Less stress on potentially ischemic myocardium owing to decreased heart rate and myocardial contractility Attenuation of effects of endogenous catecholamines Redistribution of coronary blood flow to ischemic areas Increased coronary blood flow owing to increased diastolic time Plaque stabilization owing to decrease in shear forces Cardiac antidysrhythmic effects Antiinflammatory effects (?)
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