Transfer of inhaled anesthetic from anesthetic machine to alveoli (anesthetic input)

• Inspired partial pressure

• Alveolar ventilation

• Characteristics of anesthetic breathing system

• Functional residual capacity

Transfer of inhaled anesthetic from alveoli to arterial blood (anesthetic loss)

• Blood:gas partition coefficient

• Cardiac output

• Alveolar-to-venous partial pressure difference

Transfer of inhaled anesthetic from arterial blood to brain (anesthetic loss)

• Brain:blood partition coefficient

• Cerebral blood flow

• Arterial-to-venous partial pressure difference