The Relationship Between Volume and Clearance and Half-Life Can Be Envisioned by Considering Two Settings: a Big Volume and a Small Clearance (A) and a Small Volume With a Big Clearance (B) Drug Will Be Eliminated Faster in the Latter Case.

(From Murray RK, Granner DK, Mayes PA, et al. Harper’s Biochemistry. 21st ed. Norwalk, CT: Appleton & Lange; 1988, with permission.)

The relationship between volume and clearance and half-life can be envisioned by considering two settings: a big volume and a small clearance (A) and a small volume with a big clearance (B). Drug will be eliminated faster in the latter case.