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Table 19-6

Comparative Pharmacologic Effects of Calcium Channel Blockers

VerapamilNifedipineNicardipineDiltiazem
Systemic blood pressureDecreaseDecreaseDecreaseDecrease
Heart ratesDecreaseIncrease to no changeIncrease to no changeDecrease
Myocardial depressionModerateModerateSlightModerate
Sinoatrial node depressionModerateNoneNoneSlight
Atrioventricular node conductionMarkedNoneNoneModerate depression
Coronary artery dilationModerateMarkedGreatestModerate
Peripheral artery dilationModerateMarkedMarkedModerate