Comparative Solubilities of Inhaled Anesthetics
| Blood:Gas Partition Coefficient | Brain:Blood Partition Coefficient | Muscle:Blood Partition Coefficient | Fat:Blood Partition Coefficient | Oil:Gas Partition Coefficient | | Soluble | | Methoxyflurane | 12 | 2 | 1.3 | 48.8 | 970 | | Intermediately soluble | | Halothane | 2.54 | 1.9 | 3.4 | 51.1 | 224 | | Enflurane | 1.90 | 1.5 | 1.7 | 36.2 | 98 | | Isoflurane | 1.46 | 1.6 | 2.9 | 44.9 | 98 | | Poorly soluble | | Nitrous oxide | 0.46 | 1.1 | 1.2 | 2.3 | 1.4 | | Desflurane | 0.42 | 1.3 | 2.0 | 27.2 | 18.7 | | Sevoflurane | 0.69 | 1.7 | 3.1 | 47.5 | 55 | | Xenon | 0.115 | | | | |
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Source: Data from Eger EI. Desflurane (Suprane): A Compendium and Reference. Nutley, NJ: Anaquest; 1993:1-119; and Yasuda N, Targ AC, Eger EI. Solubility of I-653, sevoflurane, isoflurane, and halothane in human tissues. Anesth Analg. 1989;69:370-373.