After Discontinuation of Amiodarone, the Plasma Concentration Decreases Slowly, Resulting in a Prolonged Elimination Half-Time

(From Kannan R, Nademannee K, Hendrickson JA, et al. Amiodarone kinetics after oral doses. Clin Pharmacol Ther. 1982;31:438-444, with permission.)

After discontinuation of amiodarone, the plasma concentration decreases slowly, resulting in a prolonged elimination half-time.