Time Course of Opioid Withdrawal
| Opioid | Onset | Peak Intensity | Duration | | Meperidine | 2-6 h | 6-12 h | 4-5 days | | Fentanyl | 2-6 h | 6-12 h | 4-5 days | | Morphine | 6-18 h | 36-72 h | 7-10 days | | Heroin | 6-18 h | 36-72 h | 7-10 days | | Methadone | 24-48 h | 3-21 days | 6-7 weeks |
|
Adapted from Mitra S, Sinatra RS. Perioperative management of acute pain in the opioid-dependent patient. Anesthesiology. 2004;101:212-227.