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Table 10-2

Dose-Dependent Effects of Lidocaine

Plasma Lidocaine Concentration (μg/mL)Effect
1-5Analgesia
5-10Circumoral numbness
Tinnitus
Skeletal muscle twitching
Systemic hypotension
Myocardial depression
10-15Seizures
Unconsciousness
15-25Apnea
Coma
>25Cardiovascular depression