Heparin Administration is Associated With Decreased Plasma Protein Binding of Propranolol Manifesting As an Increased Plasma Concentration of Free (Unbound) Drug (Mean ± Se; *p <.05.) Sicu, Surgical Intensive Care Unit.

(From Wood M, Shand DG, Wood AJ. Propranolol binding in plasma during cardiopulmonary bypass. Anesthesiology. 1979;51:512-516, with permission.)

Heparin administration is associated with decreased plasma protein binding of propranolol manifesting as an increased plasma concentration of free (unbound) drug. (Mean ± SE; *P <.05.) SICU, surgical intensive care unit.