Local Anesthetics Consist of a Lipophilic and Hydrophilic Portion Separated by a Connecting Hydrocarbon Chain

(Reproduced from Cipollone F, Santovito D. EP receptors and coxibs: seeing the light at the end of the tunnel. Circ Res. 2013;113:91-93.)

ECs, endothelial cells; EP, PGE2 receptor; DP, PGD2 receptor; FP, PGF2α receptor; IP, prostacyclin receptor; PLTs, platelets; TP, thromboxane receptor; and VSMCs, vascular smooth muscle cells.