The Time to Peak Effect and t ½ ke0 following a Bolus Dose

The Time to Peak Effect and t ½ k_e0 following a Bolus Dose

Drug	Time to Peak Drug Effect (min)	t ½ k_e0 (min)^a
Fentanyl	3.6	4.7
Alfentanil	1.4	0.9
Sufentanil	5.6	3.0
Remifentanil	1.6	1.3
Propofol	2.2	2.4
Thiopental	1.6	1.5
Midazolam	2.8	4.0
Etomidate	2.0	1.5

^a t ½ k_e0 = 0.693 / k_e0, the effect site half-life, where k_e0 is the rate constant for elimination of drug from the site of drug effect and t ½ k_e0 is the time required for the concentration at the site of drug effect to fall to half of its value.

Reused from Glass PSA, Shafer S, Reves JG. Intravenous drug delivery systems. In: Miller RD, Eriksson LI, Fleisher LA, et al, eds. Miller’s Anesthesia. 7th ed. Philadelphia, PA: Churchill Livingstone; 2010, with permission.

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Table 2-2