Fentanyl Infusion Rate to Maintain a Plasma Concentration of 1 μG/Hr The Rate Starts Off Quite High Because Fentanyl is Avidly Taken Up by Body Fat. The Necessary Infusion Rate Decreases As the Fat Equilibrates With the Plasma.

(Reused from Scott JC, Stanski DR. Decreased fentanyl and alfentanil dose requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation. J Pharmacol Exp Ther. 1987;240:159-166.)

Fentanyl infusion rate to maintain a plasma concentration of 1 μg/hr. The rate starts off quite high because fentanyl is avidly taken up by body fat. The necessary infusion rate decreases as the fat equilibrates with the plasma.