Schematic Diagram Showing G Protein-Coupled Receptors, the beta2-Adrenergic Receptor, Which Upregulates Adenylyl Cyclase, and the M2 Muscarinic Receptor, Which Downregulates Adenylyl Cyclase (AC) The Effects of These G Protein-Coupled Receptors are Then Mediated through the Intercellular Concentration of Cyclic Amp.

(Modified from Pierre S, Eschenhagen T, Geisslinger G, et al. Capturing adenylyl cyclases as potential drug targets. Nat Rev Drug Discov. 2009;8:321-335.)

Schematic diagram showing G protein-coupled receptors, the 2-adrenergic receptor, which upregulates adenylyl cyclase, and the M2 muscarinic receptor, which downregulates adenylyl cyclase (AC). The effects of these G protein-coupled receptors are then mediated through the intercellular concentration of cyclic AMP.