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Table 9-1

Characteristics of Commonly Prescribed Nonsteroidal Antiinflammatory Drugs

DoseaPharmacokinetics
Generic Name (Trade Name)Available Dosages (mg)Common Dosing IntervalsDrug MetabolismElimination Half-Life (h)
Nonselective NSAIDs Acetic Acid Group
Diclofenac DR25BID-TIDOxidation1-2
(Voltaren)50QD-BID
Diclofenac XR75
(Voltaren XR)100
Etodolac200BID-TIDOxidation, conjugation7
(Lodine)300QD
Etodolac XL400
(Lodine XL)500
400
500
600
Ketorolac IM, IV injection30QD-QIDConjugation2.5-8.5
(generic)
Indomethacin25BID-TIDOxidation, conjugation4.5-6
(Indocin)50QD-BID
Indomethacin SR75
(Indocin SR)
Nabumetone500QD-BIDOxidation22-30
(Relafen)750
Sulindac150BIDOxidation, reduction16
(Clinoril)200
Tolmetin400TIDConjugation5
(Tolectin)600
Oxicam Group
Meloxicam7.5QDOxidation13-20
(Mobic)15
Piroxicam10QDOxidation30-86
(Feldene)20
Propionic Acid Group
Fenoprofen200TID-QIDGlucuronidation3
(Nalfon)300
Flurbiprofen50BID-QIDOxidation3-6
(Ocufen)100
Ibuprofen400TID-QIDOxidation2-2.5
(Motrin)600
800
Ketoprofen50TID-QIDConjugation2-4
75QD3-7
Ketoprofen CR100
150
200
Naproxen250BIDConjugation, oxidation12-15
(Naprosyn)375QD
(Naprelan)500
375
500
Oxaprozin (Daypro)600QD-BIDOxidation, conjugation50-60
Salicylate
Aspirin81QDHydrolysis, conjugation, glucuronidation0.25-0.5
(Ecotrin, Ascriptin)325BID-QID
Choline magnesium500BID-TID
500
Trisalicylate750Conjugation2-12
(Trilisate)1000
Cyclooxygenase-2 Agents Coxib Group
Celecoxib100QD-BIDConjugation11-16
(Celebrex)200

aA dosage range exists for each NSAID that must be individualized depending on patient characteristics and disease mechanism.

Reproduced from Vincent JL, Abraham E, Moore FA, et al. Textbook of Critical Care, 6th ed. Philadelphia, PA: Elsevier Saunders; 2011:1346-1353.