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Table 30-5

Properties of Glycoprotein IIb/IIIa Antagonists

DrugStructureRoute of AdministrationElimination Half-Time (h)ExcretionClinical UsesStop before Surgery (h)Prolong PT/PTTAntidote
AbciximabMonoclonal antibodiesIntravenous12-24Plasma proteases

  • ACS

  • PCI

72No/NoDialysis
EptifibatidePeptideIntravenous2-4Renal

  • ACS

  • PCI

24No/NoDialysis
TirofibanNonpeptideIntravenous2-4

  • Renal (30%-60%)

  • Biliary (40%-70%)

ACS24No/NoDialysis