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Table 9-3

Comparative Pharmacology of Endogenous and Synthetic Corticosteroids

Antiinflammatory PotencySodium Retaining PotencyEquivalent Dose (mg)Elimination Half-Time (h)Duration of Action (h)Route of Administration
Cortisol11201.5-3.08-12Oral, topical, IV, IM, IA
Cortisone0.80.8250.58-36Oral, topical, IV, IM, IA
Prednisolone40.852-412-36Oral, topical, IV, IM, IA
Prednisone40.852-412-36Oral
Methylprednisolone50.542-412-36Oral, topical, IV, IM, IA, epidural
Betamethasone2500.75536-54Oral, topical, IV, IM, IA
Dexamethasone2500.753.5-5.036-54Oral, topical, IV, IM, IA
Triamcinolone5043.512-36Oral, topical, IV, IM, epidural
Fludrocortisone10250224Oral, topical, IV, IM
Aldosterone03,000