An intrapleural drug is injected through the chest wall into the pleural space or instilled through a chest tube placed intrapleurally for drainage.1 (For more information on chest tube insertion, see the "Chest tube insertion, assisting" procedure.) During intrapleural injection of a drug, the needle passes through the intercostal muscles and parietal pleura on its way to the pleural space. (See Inserting an intrapleural catheter.) Intrapleurally administered drugs diffuse across the parietal pleura and innermost intercostal muscles to affect the intercostal nerves.
Practitioners use intrapleural administration to promote analgesia, treat spontaneous pneumothorax, resolve pleural effusion, and administer chemotherapy.1 Drugs commonly given by intrapleural injection include tetracycline, tissue plasminogen activator and deoxyribonuclease, streptokinase, anesthetics, sterile talc, biotherapy agents, and chemotherapeutic agents (to treat malignant pleural effusion or tumors).4 Note that the use of some of these medications, such as tissue plasminogen activator, in the intrapleural space may be off-label.
Contraindications for drug administration by this route include pleural fibrosis or adhesions, which interfere with diffusion of the drug to the intended site; pleural inflammation; sepsis; and infection at the puncture site. Patients with bullous emphysema and those receiving respiratory therapy using positive end-expiratory pressure shouldnt receive intrapleural injections because they may exacerbate an already compromised pulmonary condition.
Computed tomography scans or chest X-rays of the retained pleural fluid or fluid pockets may be completed, and must be evaluated, by the practitioner before administration of certain intrapleural drugs, such as tissue plasminogen activator. Imaging may be repeated with each administration to evaluate the patients response to therapy. Follow-up imaging and other assessment findings may be used to evaluate the effectiveness of intrapleural therapy.
Nurses should consult their state nurse practice act and facility guidelines to determine whether this procedure is within their scope of practice. Additionally, specialized training or competency measurement may also be required. Follow your facility guidelines. This procedure covers administration through an intrapleural chest tube or intrapleural catheter.
An intrapleural drug is typically administered through a 16G to18G blunt-tipped intrapleural (epidural) needle and catheter. Accessory equipment depends on the type of access device the practitioner uses. All equipment must be sterile.
Gloves sterile gauze pads antiseptic solution prescribed medication appropriate-sized needles and syringes dressings tape chest tube clamp stethoscope marker vital sings monitoring equipment Optional: 1% lidocaine.
Label all medications and solutions on and off the sterile field to prevent medication administration errors.
Inspect all equipment and supplies. If a product is expired, is defective, or has compromised integrity, remove it from patient use, label it as expired or defective, and report the expiration or defect as directed by your facility.
Follow the manufacturers instructions for preparation of prescribed medication, if necessary.
NURSING ALERT Never use a medication thats cloudy or discolored or that contains a precipitate unless the manufacturers instructions allow it. Remember the presence of drug particles is normal for some drugs (such as suspensions). If in doubt, check with the pharmacist.
NURSING ALERT If required by your facility, before administering a medication by the intrapleural route, have another nurse or the practitioner perform an independent double-check to verify the patients identity and to make sure that you have the correct medication in the prescribed strength or concentration; the medications indication corresponds with the patients diagnosis; the dosage calculations are correct and the dosing formula used to derive the final dose is correct; the prescribed route of administration is safe and proper for the patient; the prescribed time and frequency of administration are safe and proper for the patient; and, if an infusion, the pump settings are correct and the infusion line is attached to the correct port.27,28
Advise the patient to report any difficulty with breathing, pain experienced during the procedure, or drainage from the chest tube insertion site.42
Pneumothorax or tension pneumothorax may occur if the practitioner accidentally injects air into the pleural cavity. These complications are more likely to occur in a patient who is on mechanical ventilation.
Accidental catheter placement in the lung can lead to respiratory distress; catheter placement within a vessel can increase the medications effects; and laceration of intercostal vessels may cause bleeding. If the catheter fractures, lung puncture may occur.
Local anesthetic toxicity can lead to tinnitus, metallic taste, light-headedness, somnolence, visual and auditory disturbances, restlessness, delirium, slurred speech, nystagmus, muscle tremor, seizures, arrhythmias, and cardiovascular collapse. A local anesthetic containing epinephrine can cause tachycardia and hypertension.
Failure to adhere to sterile technique may lead to infection.
Other complications specific to the medication being administered should be discussed with the patient as well.
Document the date and time of access to the intrapleural catheter or chest tube, the practitioners name, and the patients tolerance of the procedure. Document any premedication that you administered before the procedure. Document all preprocedure verification, including the people involved in the verification process. For drug administration, record the date, time, drug administered, drug dosage and strength, sequence of drug administration (if appropriate), route of administration, patients response to the treatment, and condition of the catheter or chest tube insertion site. Document the patients vital signs before and after medication administration, as well as the volume and visual characteristics of chest tube fluid drainage before and after medication administration. Also note any adverse reactions to the medication, the date and time that you notified the practitioner, the prescribed interventions, and the patients response to those interventions. Document teaching that you provided to the patient and family (if applicable), their understanding of that teaching, and any need for follow-up teaching.
Interruptions lead to errors and unfinished...Wait, what was I doing?
Nurse Advise-ERR, 11(2), 14. https://www.ismp.org/resources/side-tracks-safety-express-interruptions-lead-errors-and-unfinished-wait-what-was-i-doing?id=37Nursing services. 42 C.F.R. § 482.23 (c)
.Accreditation requirements for acute care hospitals
. Chicago, IL: Accreditation Association for Hospitals and Health Systems. (Level VII)Accreditation requirements for acute care hospitals
. Chicago, IL: Accreditation Association for Hospitals and Health Systems. (Level VII)Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force
. MMWR Recommendations and Reports, 51(RR-16), 145. https://www.cdc.gov/mmwr/pdf/rr/rr5116.pdf (Level II)Infection control. 42 C.F.R. § 482.42
.Accreditation requirements for acute care hospitals
. Chicago, IL: Accreditation Association for Hospitals and Health Systems. (Level VII)Patients rights. 42 C.F.R. § 482.13 (c)(1)
.Accreditation requirements for acute care hospitals
. Chicago, IL: Accreditation Association for Hospitals and Health Systems. (Level VII)A toolkit for improving quality of care
(AHRQ Publication No. 13-0015-EF). Rockville, MD: Agency for Healthcare Research and Quality. https://www.ahrq.gov/sites/default/files/publications/files/fallpxtoolkit_0.pdf (Level VII)Accreditation requirements for acute care hospitals
. Chicago, IL: Accreditation Association for Hospitals and Health Systems. (Level VII)Medical record services. 42 C.F.R. § 482.24(b)
.Accreditation requirements for acute care hospitals
. Chicago, IL: Accreditation Association for Hospitals and Health Systems. (Level VII)maintenance
. The JBI EBP Database. AN: JBI-ES-1241-1