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Introduction

An intrapleural drug is injected through the chest wall into the pleural space or instilled through a chest tube placed intrapleurally for drainage.1 (For more information on chest tube insertion, see the "Chest tube insertion, assisting" procedure.) During intrapleural injection of a drug, the needle passes through the intercostal muscles and parietal pleura on its way to the pleural space. (See Inserting an intrapleural catheter.) Intrapleurally administered drugs diffuse across the parietal pleura and innermost intercostal muscles to affect the intercostal nerves.

Practitioners use intrapleural administration to promote analgesia, treat spontaneous pneumothorax, resolve pleural effusion, and administer chemotherapy.1 Drugs commonly given by intrapleural injection include tetracycline, tissue plasminogen activator and deoxyribonuclease, streptokinase, anesthetics, sterile talc, biotherapy agents, and chemotherapeutic agents (to treat malignant pleural effusion or tumors).4 Note that the use of some of these medications, such as tissue plasminogen activator, in the intrapleural space may be off-label.

Contraindications for drug administration by this route include pleural fibrosis or adhesions, which interfere with diffusion of the drug to the intended site; pleural inflammation; sepsis; and infection at the puncture site. Patients with bullous emphysema and those receiving respiratory therapy using positive end-expiratory pressure shouldn’t receive intrapleural injections because they may exacerbate an already compromised pulmonary condition.

Computed tomography scans or chest X-rays of the retained pleural fluid or fluid pockets may be completed, and must be evaluated, by the practitioner before administration of certain intrapleural drugs, such as tissue plasminogen activator. Imaging may be repeated with each administration to evaluate the patient’s response to therapy. Follow-up imaging and other assessment findings may be used to evaluate the effectiveness of intrapleural therapy.

Nurses should consult their state nurse practice act and facility guidelines to determine whether this procedure is within their scope of practice. Additionally, specialized training or competency measurement may also be required. Follow your facility guidelines. This procedure covers administration through an intrapleural chest tube or intrapleural catheter.

Equipment

Equipment

An intrapleural drug is typically administered through a 16G to18G blunt-tipped intrapleural (epidural) needle and catheter. Accessory equipment depends on the type of access device the practitioner uses. All equipment must be sterile.

Gloves • sterile gauze pads • antiseptic solution • prescribed medication • appropriate-sized needles and syringes • dressings • tape • chest tube clamp • stethoscope • marker • vital sings monitoring equipment • Optional: 1% lidocaine.

Preparation of Equipment

Preparation of equipment

Label all medications and solutions on and off the sterile field to prevent medication administration errors.

Inspect all equipment and supplies. If a product is expired, is defective, or has compromised integrity, remove it from patient use, label it as expired or defective, and report the expiration or defect as directed by your facility.

Follow the manufacturer’s instructions for preparation of prescribed medication, if necessary.

Implementation

Implementation
  • Avoid distractions and interruptions when preparing and administering medications to prevent medication administration errors.5,6
  • Verify the practitioner’s order.7,8,9,10
  • Review the order to make sure that the prescribed medication dose, rate, and route of administration are appropriate for the patient’s age, condition and access device. Address concerns about the order with the practitioner, the pharmacist, or your supervisor, and, if needed, the risk management department or as directed by your facility.7,11
  • Gather and prepare the necessary equipment and supplies.
  • Compare the medication label with the order in the patient’s medical record.8,9,10,11,12
  • Check the expiration date on the medication.11 If the medication is expired, return it to the pharmacy and obtain a new medication.8,9,10,12
  • Check the patient’s medical record for an allergy or other contraindication to the prescribed medication. If an allergy or other contraindication exists, don’t administer the medication; notify the practitioner.8,9,11,13
  • Visually inspect the medication for discoloration or other indication of loss of integrity. Don’t administer the medication if its integrity is compromised.8,9,10,11,12

NURSING ALERT Never use a medication that’s cloudy or discolored or that contains a precipitate unless the manufacturer’s instructions allow it. Remember the presence of drug particles is normal for some drugs (such as suspensions). If in doubt, check with the pharmacist.

  • Discuss any unresolved concerns about the medication with the patient’s practitioner.8,9,10,11
  • Coordinate with the ordering practitioner and the radiography department to ensure that a chest X-ray is obtained before medication administration, if necessary, for use as a baseline to monitor the effect of medication.
  • Perform hand hygiene.14,15,16,17,18,19
  • Confirm the patient’s identity using at least two patient identifiers.20
  • Provide privacy.21,22,23,24
  • Explain the procedure to the patient and family (if appropriate) according to their individual communication and learning needs to increase their understanding, allay their fears, and enhance cooperation.25
  • If the patient is receiving the medication for the first time, teach the patient and family (as appropriate) about potential adverse effects and any other concerns related to the medication.8,9,10,12,26
  • Verify that the medication is being administered at the proper time, in the prescribed dose, and by the correct route to reduce the risk of medication errors.8,9,12,13
  • If your facility uses bar-code technology, use it as directed by your facility.11

NURSING ALERT If required by your facility, before administering a medication by the intrapleural route, have another nurse or the practitioner perform an independent double-check to verify the patient’s identity and to make sure that you have the correct medication in the prescribed strength or concentration; the medication’s indication corresponds with the patient’s diagnosis; the dosage calculations are correct and the dosing formula used to derive the final dose is correct; the prescribed route of administration is safe and proper for the patient; the prescribed time and frequency of administration are safe and proper for the patient; and, if an infusion, the pump settings are correct and the infusion line is attached to the correct port.27,28

  • After comparing results of the independent double-check with the other nurse, administer the medication if there are no discrepancies. If discrepancies exist, rectify them before administering the medication.27
  • Have the patient lie supine in the bed with the head of the bed at a comfortable level.
  • Raise the bed to waist level before providing care to prevent caregiver back strain.29
  • Perform hand hygiene.14,15,16,17,18,19
  • Put on clean gloves to comply with standard precautions.30,31,32
  • Obtain the patient’s vital signs, including auscultation of the lungs bilaterally, to serve as baselines for comparison.33
  • Screen for and assess the patient’s pain using a facility-approved pain assessment tool that’s consistent with the patient’s age, condition, and ability to understand.34
  • Treat the patient’s pain, as needed and ordered, using nonpharmacologic, pharmacologic, or a combination of approaches. Base the treatment plan on evidence-based practices and the patient’s clinical condition, past medical history, and pain management goals.34
  • Assess the integrity of the drainage system tubing and chest tube to ensure that the drainage system is intact, with no air leaks or kinks, and to help prevent clot formation.35
  • Note the character, consistency, and amount of drainage in the chest tube drainage collection unit chamber. Mark the drainage level by writing the time and date at the drainage level on the drainage collection chamber to accurately monitor output after medication administration.36,37
  • Remove and discard your gloves.30,32
  • Perform hand hygiene.14,15,16,17,18,19
  • Put on gloves to comply with standard precautions.30,31,32
  • Turn off the suction, if applicable.
  • Position the patient with the affected side up to gain access to the injection port.
  • Assist the practitioner with removing the dressing from the intrapleural catheter or chest tube, if indicated, and clamp the drainage tube if one is present.36
  • Discard the dressing in the appropriate receptacle.30
  • Remove and discard your gloves.30
  • Perform hand hygiene.14,15,16,17,18,19
  • Put on gloves to comply with standard precautions.30,31,32
  • Trace the tubing from the patient to its point of origin to make sure that the medication is being administered into the correct port.38,39
  • If a stopcock is in place, and if appropriate to the medication being administered, turn the lever to point to the chest tube drain to stop the flow from going into the drainage collection device.40
  • Disinfect the access port of the catheter or chest tube with an antiseptic-soaked gauze pad and then allow it to dry.
  • Connect the prepared prescribed medication to the port and administer the medication as ordered following safe medication administration practices.36,41
  • Disinfect the access port of the catheter or chest tube with an antiseptic-soaked gauze pad and then allow it to dry.
  • Flush the intrapleural chest tube or intrapleural catheter with sterile normal saline, as ordered, following safe medication administration practices.41
  • If ordered, keep the chest tube or catheter clamped for the prescribed dwell time.36,41,42
  • Obtain the patient’s vital signs at a frequency determined by your facility, including auscultation of lungs bilaterally, and monitor the patient for signs of discomfort.36,42
  • Reassess the patient’s pain and assess for any adverse reactions or events from treatment. Notify the practitioner immediately if any such event occurs.34
  • Unclamp the chest tube after the ordered dwell time and turn the suction back on, if ordered and applicable.41
  • Return the stopcock lever to the open position, if applicable, to allow drainage to collect in the drainage collection system.36,42
  • Observe the type, color, and amount of drainage in the drainage collection chamber. Immediately notify the practitioner of a sudden increase in drainage or frank bloody drainage.37
  • Return the bed to the lowest position to prevent falls and maintain patient safety.43
  • Discard used supplies in appropriate receptacles.30
  • Remove and discard your gloves.31,41
  • Perform hand hygiene.14,15,16,17,18,19
  • Clean and disinfect your stethoscope using a disinfectant pad.44,45
  • Perform hand hygiene.14,15,16,17,18,19
  • Document the procedure.46,47,48,49

Special Considerations

Special considerations
  • The Joint Commission issued a sentinel event alert related to managing risk during transition to new International Organization for Standardization tubing standards designed to prevent dangerous tubing misconnections, which can lead to serious patient injury and death. During the transition, trace all tubing and catheters from the patient to their points of origin before connecting or reconnecting any device or infusion, at any care transition (such as to a new setting or service), and as part of the hand-off process. Route tubes and catheters with different purposes in different, standardized directions; label the tubing at the distal and proximal ends when there are different access sites or several bags hanging; use tubing and equipment only as intended; and store medications for different delivery routes in separate locations.39
  • If the chest tube dislodges, cover the site at once with a sterile gauze pad and tape it in place on only three sides to prevent the risk of pneumothorax.50 Stay with the patient, monitor vital signs, and observe carefully for signs and symptoms of tension pneumothorax: hypotension, distended jugular veins, absent breath sounds, tracheal shift, hypoxemia, dyspnea, tachypnea, diaphoresis, chest pain, and a weak, rapid pulse. Have another nurse call the practitioner and gather the equipment for reinsertion.
  • For a patient with a chest tube, keep clamps at the bedside. If a commercial chest tube system cracks or a tube disconnects, use the clamps to clamp the chest tube close to the insertion site.35 As an alternative to clamping the tube, submerge the distal end of the tube in a bottle of sterile water to create a temporary water seal while you replace the drainage system. Notify the practitioner. Be sure to observe the patient closely for signs of tension pneumothorax, because no air can escape from the pleural space while the tube is clamped.35

Patient Teaching

Patient teaching

Advise the patient to report any difficulty with breathing, pain experienced during the procedure, or drainage from the chest tube insertion site.42

Complications

Complications

Pneumothorax or tension pneumothorax may occur if the practitioner accidentally injects air into the pleural cavity. These complications are more likely to occur in a patient who is on mechanical ventilation.

Accidental catheter placement in the lung can lead to respiratory distress; catheter placement within a vessel can increase the medication’s effects; and laceration of intercostal vessels may cause bleeding. If the catheter fractures, lung puncture may occur.

Local anesthetic toxicity can lead to tinnitus, metallic taste, light-headedness, somnolence, visual and auditory disturbances, restlessness, delirium, slurred speech, nystagmus, muscle tremor, seizures, arrhythmias, and cardiovascular collapse. A local anesthetic containing epinephrine can cause tachycardia and hypertension.

Failure to adhere to sterile technique may lead to infection.

Other complications specific to the medication being administered should be discussed with the patient as well.

Documentation

Documentation

Document the date and time of access to the intrapleural catheter or chest tube, the practitioner’s name, and the patient’s tolerance of the procedure. Document any premedication that you administered before the procedure. Document all preprocedure verification, including the people involved in the verification process. For drug administration, record the date, time, drug administered, drug dosage and strength, sequence of drug administration (if appropriate), route of administration, patient’s response to the treatment, and condition of the catheter or chest tube insertion site. Document the patient’s vital signs before and after medication administration, as well as the volume and visual characteristics of chest tube fluid drainage before and after medication administration. Also note any adverse reactions to the medication, the date and time that you notified the practitioner, the prescribed interventions, and the patient’s response to those interventions. Document teaching that you provided to the patient and family (if applicable), their understanding of that teaching, and any need for follow-up teaching.

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