In-line filters are used to prevent undesirable substances from entering the vascular system. The size and type of filter required is determined by the type of infusate; follow the manufacturer’s instructions for use. The filter may be an add-on device or part of the IV administration set tubing. Consult the information below about filter use, or check with a pharmacist and the manufacturer’s specific recommendations if you’re unsure about the type of filter to use or whether a filter is required.^23,24,25

• Apply or replace an in-line filter with each change of the IV administration set.
• When administering lipid infusions or 3-in-1 parenteral nutrition solutions, use a 1.2-micron filter, which retains particles and eliminates air.
• When administering nonlipid-containing solutions that require filtration, use a 0.2-micron filter, which retains bacteria and particulates and eliminates air.
• When using an electronic infusion device, ensure that the pounds per square inch (psi) rating of the filter exceeds the psi exerted by the electronic infusion device.
• Don’t administer small-volume infusions of 5 mL or less over 24 hours through a 0.2-micron filter.
• Don’t administer IV push medications through a 0.2-micron filter.