Metabolic & Systemic
- Diabetes mellitus
- Alcoholism
- Uremia
- Thiamine deficiency
- Vitamin B12 deficiency
- Multiple myeloma
- Amyloidosis
- Cryoglobulinemia
- Hypothyroidism or hyperthyroidism
- Sarcoidosis
- Paraneoplastic syndrome, eg, lung cancer
- Neuropathy associated with critical illness
Infectious & Inflammatory
- Hansen’s disease (leprosy)
- HIV/AIDS
- Lyme disease
- Diphtheritic neuropathy
- Polyarteritis nodosa
- Rheumatoid arthritis
- Temporal (giant cell) arteritis
Toxic
- Metals: lead, mercury, arsenic, thallium
- Drugs: isoniazid, phenytoin, pyridoxine, nitrofurantoin, vincristine
- Industrial agents or pesticides: acrylamide, organophosphates, hexacarbon solvents, methyl bromide, carbon disulfide
Hereditary
- Charcot-Marie-Tooth disease (hereditary motor and sensory neuropathy, HMSN type I & II)
- Porphyria
- Friedrich’s ataxia
- Dejerine-Sottas disease (HMSN type III)
- Refsum disease (HMSN type IV)
Mostly motor
- Guillain-Barré syndrome
- Chronic inflammatory demyelinating polyneuropathy (CIDP)
- Porphyria
- Diphtheritic neuropathy
- Toxic neuropathy
- Poliomyelitis
- Periodic paralysis syndrome
Outline