Medical

• Malignancy
• Gastrointestinal disorders, eg, malabsorption, pancreatic insufficiency, peptic ulcer
• Hyperthyroidism
• Chronic heart, lung, or renal disease
• Uncontrolled diabetes mellitus
• Intestinal ischemia
• Dysphagia
• Anorexia due to azotemia
• Hypercalcemia
• Tuberculosis
• Subacute bacterial endocarditis

Psychosocial

• Depression
• Dementia
• Alcoholism
• Anorexia nervosa
• Loss of teeth, poor denture fit
• Social isolation
• Poverty
• Inability to buy or prepare food

Drug related

• NSAIDs
• Antiepileptics
• Digoxin
• SSRIs

• Fatigue
• Fever of unknown origin