• Thrombotic thrombocytopenic purpura
• Acute leukemia
• Myelodysplastic syndrome
• Disseminated intravascular coagulation
• Early aplastic anemia
• Drug toxicity, eg, heparin, sulfonamides, thiazides, quinine
• Alcohol abuse
• Hypersplenism
• Systemic lupus erythematosus

Associated conditions

• HIV infection
• Autoimmune disease, eg, systemic lupus erythematosus
• Lymphoproliferative disease
• Evans syndrome (idiopathic thrombocytopenic purpura with autoimmune hemolytic anemia)

• Thrombocytopenia
• Bleeding, general approach
• Epistaxis
• Nonpalpable purpura
• Menorrhagia