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Table 1

Drugs and Dosages Used to Manage Feline Urine Marking

DrugDrug ClassOral Dosage in CatsFrequencySide Effects (Usually Transient)
FluoxetineSSRI0.5–1.0 mg/kgq24hDecreased appetite, sleepiness
ParoxetineSSRI0.25–0.50 mg/kgq24hConstipation
ClomipramineTCA0.2–0.50 mg/kgq24hSleepiness
AmitriptylineTCA0.25–1.0 mg/kgq24hSleepiness
BuspironeAzapirone0.5–1.0 mg/kgq12hGIT side effects (rare)