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Basics

Basics

Definition

  • Fear-involuntary, negative emotional state caused by the anticipation/awareness of danger.
  • Aggression-warning/intent to cause harm/increase distance in response to perceived threat.

Pathophysiology

See “Causes” and “Risk Factors”

Systems Affected

  • Behavioral-neurochemical input between the limbic system and forebrain allow for classically conditioned emotional (fear) memories, leads to defensive behavioral response.
  • Sympathetic nervous system arousal.

Genetics

Fearful/fractious temperaments are heritable.

Incidence/Prevalence

N/A

Geographic Distribution

N/A

Signalment

Species

Dog and cat

Breed Predilections

Any

Mean Age and Range

Any

Predominant Sex

Any

Signs

General Comments

  • Displacement behaviors (yawns, lip licking, grooming, panting).
  • Offensive and/or defensive threat displays.
  • “4 F's of behavior”: fight, flight, freeze, fidget.

Causes

  • Previous/current frightening or painful veterinary visits create an involuntary fear response (“white coat effect”).
  • Previous use of harsh/punitive tones of voice, physical manipulation.
  • Additional exposure to individual patient's triggers of fear (travel, dogs, strangers).
  • Underlying fearful/anxious temperament; comorbid behavioral disorders.

Risk Factors

  • Previous frightening/painful veterinary experiences.
  • History of fearful/fractious behavior at previous visits or around any person.
  • Harsh or punitive handling during puppy or kitten visits.
  • Poor socialization during the sensitive socialization period (dog 3–12 wks; cat 2–7 wks).

Diagnosis

Diagnosis

Differential Diagnosis

  • Pain
  • Irritability from illness-gastrointestinal discomfort, urogenital inflammation, visceral neoplasia
  • Forebrain lesion
  • Cognitive dysfunction syndrome

CBC/Biochemistry/Urinalysis

Endogenous corticosteroid-induced (stress) leukogram possible (neutrophilia, lymphopenia, monocytosis); hyperglycemia; glucosuria (cats)

Other Laboratory Tests

N/A

Imaging

N/A

Diagnostic Procedures

N/A

Pathologic Findings

N/A

Treatment

Treatment

Appropriate Health Care

Prior to Handling

Assess the environment, patient and yourself. What patients see, smell, feel, taste, and hear affect emotional state. Utilize assessments to ameliorate stressors and create a successful handling plan.

Assess the Environment: make it comfortable for the patient

  • Eliminate exposure to patient's known triggers of fear or aggression.
  • Reduce environmental stimuli (light, noise, movement, touch).
  • Thermo-neutral comfort zone is 59–86°F, dogs; 86–100°F, cats.
  • Ideal ambient sound level is 60 dB (stress at 85 dB).
  • Provide pheromone support (Adaptil, Feliway).
  • Mindfully manipulate owner presence; many do better with social support.
  • Utilize highly palatable food for distraction and CC.
  • Create a comfortable exam site (no slippery, shiny, cold surfaces).
  • Provide a way for fearful patients to hide, feel covered, and protected.
  • Ensure all supplies are readily available.

Assess the Animal

  • Recognition of fear and impending aggression and interpretation of patient body language is critical.
  • Anxiety, fear, and arousal are the motivations for aggression and other fractious behavior. Early recognition improves intervention efficacy and safety, and decreases handling time.
  • Track body language, willingness to approach, interaction with the environment and people.
  • Identify displacement behaviors to flag patients that are not coping well.
  • Monitor continually. Changes in location (lobby vs. radiology), interactions (social petting vs. exam), procedures (auscultation vs. nail trim), and personnel (female vs. male) affect patients.

Assess Yourself: Avoid Perceived Threats, Track your own Body Postures and Behavior

  • Avoid direct eye contact, bending over, or putting your face near a fearful patient.
  • Bend at the knee, turn your body to the side, and squat down (when safe).
  • Avoid reaching out, petting on top of the head, sudden grabbing of the collar or body, or reaching into a carrier. Encourage patients to approach you, or have the handler they feel safe with bring them to you.
    • Cat-encourage approach by patting the surface and using a soft voice. Remove carrier tops-do not pull or dump out patients. Allow time to sniff your hand. Gently scratch under the chin and pet the side of the head if postures indicate safety. Avoid petting beyond the shoulder as it is often arousing. Start exam at the head or middle and move back; save socially invasive or painful areas for last.
    • Dog-hold your hand at your side, patting your leg gently, soft verbal encouragement, hold your palm open with valued treats if the dog approaches, and allow the dog to sniff and investigate. Gently pet under the chin and neck area; slowly move into the desired examination position. Start exam at the middle or rear and move towards the head.
  • Lack of patient approach in response to a non-threatening invitation indicates the animal is maintaining social distance. Anticipate that your approach may lead to an aggressive response.
  • If you must approach, do so from the side; work from the side and from behind the point of the shoulder.
  • Avoid front-facing interactions unless the patient's head is covered.
  • Avoid loud talking and sudden movements.
  • Work quietly, quickly, and effectively; often a narrow window of opportunity before fear and arousal escalate.
  • Encourage handlers that are fearful of working with specific patients to stop and ask their team for help; reassess if and how to proceed. Fearful animals and fearful handlers are a dangerous combination, and often escalate each other's fear, arousal, and aggressive responses. Ensure the culture supports this and the safety of each team member.
  • Monitor handler frustration. Adversarial and punitive language and interactions must be avoided.
    • Use language that is scientifically accurate and promotes patient empathy-fearful, painful, confused; and avoid choices that result in poor handling and may be offensive to clients-mean, bad, stupid, spiteful, evil, dominant. Handler language affects their actions as well as those of others.
    • Punishment (verbal, physical, leash corrections, “dominance maneuvers”) must be strictly avoided. Aversives increase fear, arousal, aggression, and are contraindicated. Behavioral signals of intent can also be blunted, making handling more dangerous. Negative experiences are likely to escalate fractious behavior during subsequent handling interactions at the hospital and possibly at home.
    • Create cultural norms that prohibit adversarial language and interactions.

Make a Handling Plan

Handling plans are unique to individual patients/working environment, and may require adjustments dependent on patient response. Initial planning may seem time consuming, but has a high payoff in staff safety, decreased future handling time, patient welfare, and client satisfaction. Chart information including what worked well and suggested changes to make the next visit even better.

Guidelines for a Patient Handling Plan

  • Determine if and what the patient can eat; plan for CC that is appropriate and safe for the animal.
  • Select appropriate level of restraint for the individual patient and the procedures.
  • Select handling tools that increase safety and decrease patient fear and arousal.
  • Critically consider what needs to be performed-must the procedure be done today, or at all? Consider multiple visits of shorter duration with fewer procedures.
  • Place the required procedures in order of most important to least important in the event the patient is unable to tolerate all of them.
  • Place those procedures in order of least aversive to most, so early difficult procedures do not inhibit ability to complete later ones. Trends among patients exist, individual differences also occur.
  • Consider pain, invasiveness, number of procedures, and how the patient is coping with minimal handling. Consider sending the patient home with a plan for return (oral sedation prior to travel, avoidance of known triggers and environmental management, DS/CC to specific handling or tools). Use chemical restraint immediately when unlikely the patient will be able to tolerate all procedures.
  • Have chemical restraint prepared and waiting for at-risk patients; use before patient becomes aroused to promote efficacy, handler safety, and to reduce further advancement of patient fear.

Utilization of Counter-Conditioning

  • A form of classical conditioning where an animal's reflexive negative emotional response (fear) to a stimulus (veterinary setting) is changed to a positive one (pleasure). Palatable food is the easiest and most powerful means of establishing this association.
  • Prevents and/or treats established fear of handling and environment.
  • Most effective when food is first offered while the animal is relaxed and feels safe, then just before, during, and after the (aversive) procedure. Events may be aversive because they are painful (injections) or socially invasive (rectal temperature, nail trims).
  • Stressed animals may need to be fed the duration of handling to prevent escalation of fear and arousal. Utilize food that can be broken up into small pieces, or use sticky, smearable options.
  • Palatability must be high (meat baby food, liverwurst) to maximize the animal's interest in eating and increase the power of the positive emotional response. Petting and praise can be used additionally, but are far less powerful and may even be unpleasant for some pets.
  • Food serves as a “barometer” for patient stress; many won't eat even highly palatable food. Rejection should cue the handler to reassess patient comfort level, safety and handling plan.

Safe and Effective Restraint

Once the itinerary of procedures has been organized, a restraint plan should be coordinated for each procedure. Avoid the tendency to over-restrain animals. Stress often revolves around the restraint, rather than the procedure itself. When patients are CC with food, and stressors are mitigated through environmental management and non-threatening interactions with staff, less restraint is needed.

Guidelines for restraint

  • Use the least restraint required to allow the specific procedure(s) to be performed properly (AVMA Restraint Policy).
  • When greater restraint is needed, provide firm, balanced pressure with global support around the patient. Prevent flailing by keeping control of head and rear end at all times.
  • Reserve lateral recumbency in dogs only for procedures that require it (ex. orthopedic exams). It is a threatening position for many. Most can be performed in a stand or sit position. Some dogs will assume this position when lured with a treat or asked to perform a “down.” If required, prevent flailing and hitting the head; move the patient slowly and steadily with full body support.
  • Reserve scruffing and/or stretching only for cats comfortable with this technique, and only when the procedure requires the cat to be in lateral recumbency.
  • Slide your hands along the patient's body, rather than releasing and grabbing when moving your hands or adjusting your position.
  • If the pet struggles longer than 3 sec., stop, reposition, and try again. Wait until relaxed, and preferably starts eating, before beginning the procedure. If after 2 or 3 attempts the patient does not relax and/or starts to get fractious, stop altogether and consider whether the procedure is essential.
    • Essential: make a plan for chemical restraint.
    • Non-essential: send the animal home and create a plan for return.

Handling Tools

Designed to expedite veterinary procedures and increase safety. Handling tools also reduce the need for physical restraint and the stressful social interaction. The key is using them correctly, often, and early in the handling plan.

Pheromones

  • An Adaptil diffuser for dogs and Feliway diffuser for cats in the reception area, examination rooms, and hospital wards may help to lower stress.
  • A pheromone spray or wipe can be used to reduce stress during travel, crating, on the examination table or in the clinic cages. Dogs might have the spray placed on a bandana around their neck prior to the visit, or can be fitted with an Adaptil collar at least one day in advance.
  • Never spray directly on the pet.

Muzzles

  • Basket muzzle (plastic, metal):
    • Allows panting; safer for longer procedures and kenneled dogs.
    • Food can easily be smeared along the inside of the muzzle, encouraging the dog to place its nose into the muzzle.
    • Increases safety so lightest restraint and CC can be used.
    • Best if owner habituates and DS/CC to muzzle at home and have in place for arrival.
    • If owner has not adapted pet to muzzle, first consider whether procedure can be postponed and client instructed to adapt to muzzle before the next visit.
    • If staff must apply muzzle, safety is essential. Alternately, for short procedures or to facilitate an injection, a nylon slip-on muzzle might be easier to apply.[/slri]
  • Feline muzzle (leather, plastic): Select a stiff leather or plastic option that covers both mouth and eyes. Provides handler safety and minimizes visual stimuli.

Elizabethan Collar

An alternative to the muzzle for conformation or intense fear of the muzzle this collar can be used to provide control of the head. For small dogs and cats a towel or blanket may be preferable.

Towels

  • Towels or thick bedding can provide low-stress immobilization of cats and small dogs.
  • Provide head and body control, reduction of visual stimuli, and firm global pressure of handling; modifications can be made to gain access to the head.
  • Allow access for auscultation, abdominal palpation, and hind leg venipuncture.
  • Utilized to safely capture fleeing or fearful cats, remove from carrier or cage, and administer injections for chemical restraint; protect the cat from flailing and prevent bites and scratches.

Thunder Cap

  • Limits visual stimuli; reduces anticipation of procedures, perception of handler posture, and known individual triggers (travel, dogs, strangers).
  • Utilize during travel, entering to the building, procedures, hospitalization, and after chemical restraint (to keep the patient under the plane of sedation).
  • A muzzle or towel that covers the eyes/head may have the same effect on cats.

Thundershirt

Swaddles the dog or cat, providing firm, balanced pressure around the chest and torso, reducing arousal, anxiety, and fear.

Classical Music (Through a Dog's Ear/Through a Cat's Ear)

  • Increases behaviors associated with relaxation in animals and people.
  • Source of noise cancellation, masking potentially stressful external sounds.
  • Relaxes clients, reminds staff to work quietly and slowly.

Squeeze Cage

  • For essential procedures on dogs that are not safe to muzzle; protected contact used to administer injection of chemical restraint.
  • Alternative created with a chain-link panel that swings out from the wall or an existing door. Hold panel open at 90° while the dog is walked in; pull the lead through the crevice at the hinge for head control. Gently close the panel towards the wall, securing the dog; quickly inject through the panel.

Clipnosis (Cats only)

  • Pinch-based inhibition (“trance-like” state, semi-immobile, relaxed, without activation of stress response) using Clipnosis Gentle Calming Clips or other tools, such as binder clips.
  • Produces firm, even pressure when placed on the scruff, provides a hands-free option to hand-scruffing, typically with more behavioral calming.
  • Place on cats when calm and relaxed. Cats that are averse to pressure on the scruff or are fractious are not candidates.
  • Some have reservations regarding the tool and its effects on behavioral inhibition through freezing vs. calming.

Cat Carriers

  • Select type that allows the cat to easily exit on its own or have a removable top that allows the cat to remain in the bottom portion during exam.
  • Allows the cat to remain in a familiar area, prevents fleeing, and promotes hiding.
  • Soft-sided carriers useful for fractious cats in need of chemical restraint. Cat remains in the familiar carrier while the mesh panel is pressed up against the body to allow IM injection.
  • Allow hospitalized cats to have their carrier in their cage. Provides familiarity, stress relief, and has been shown to encourage a faster return to eating.
  • Carrier is a more effective tool if cats are conditioned to enter and travel in it comfortably.

EZ Nabber

  • Mesh netting tightly secured to rectangular metal enclosure; opens and closes manually to allow for capture and quick restraint.
  • Valuable for fractious cats who are fleeing or housed in a wall unit cage; 2 ft. distance between the handler and the cat.
  • Use to administer IM chemical restraint through the mesh.
  • Cover with a towel once the cat is inside to reduce visual exposure and protect handler.
  • Alternately a fish net might be used to cover or wrap the cat.

Nursing Care

N/A

Activity

N/A

Diet

N/A

Surgical Considerations

N/A

Medications

Medications

Drug(s) Of Choice

Chemical Restraint

  • Allows safe effective handling, blocking further distress. Avoid allowing patients to become fractious/agitated before considering; reduces the efficacy, allows learning to occur, advances fear responses.
  • Desired plane of sedation-animal requires little to no restraint to accomplish all desired interactions, is unaware.
  • Injectable forms of sedation IM are the most effective means of safely handling a fractious or highly fearful patient; protocol selection based on age, temperament, degree of health/disease.
  • Manage environment to achieve and maintain desired sedation (white noise, music, dim lights, owner support, avoid triggers, Thunder cap, cotton balls in ears).
  • Muzzle sedated patients for added safety.
  • Oral administration of sedative/anxiolytic medication prior to arrival so experience is less fear-provoking, safer, and requires lower doses to achieve effect.

Injectable Chemical Restraint-Dogs

  • For young fractious dogs-dexmedetomidine (10–20 µg/kg) + opioid (butorphanol* 0.2–0.4 mg/kg) IM ± ketamine (3 mg/kg) IM.
  • Alternative option-Telazol (tiletamine/zolazepam) 5–10 mg/kg IM (not practical for dogs >20 kg due to high volume injection).
  • For geriatric fractious dogs-acepromazine (0.05 mg/kg) OR dexmedetomidine (5 µg/kg) + opioid (butorphanol* 0.2–0.4mg/kg) IM.
  • Reverse dexmeditomidine with equivolume of atipamezole to volume of dexmedetomidine administered IM/SC; in ketamine protocols wait 30–60 min to reverse.

*A full Mu opioid agonist, ex. morphine (0.2 mg/kg), hydromorphone (0.05–0.1 mg/kg), or oxymorphone (0.1 mg/kg) superior for pain management

Oral transmucosal-Dogs

  • For healthy fractious dogs-dexmedetomidine (40 µg/kg) + morphine (1 mg/kg) OTM; reverse dexmeditomidine with half volume of atipamezole to volume of total dexmedetomidine IM or SC.
  • Select dogs that: are pain sensitive, allow handling of mouth by owners or staff, have been DS/CC to placement of a syringe in cheek pouch.
  • I hour to full effect; increased contact time with mucosa improves efficacy (avoid swallowing, spilling); slow application is key, increased viscosity (add honey, commercial agents) helps.
  • Often requires additional IM dose of dexmedetomidine (10 µg/kg) + morphine (0.1–0.2 mg/kg); 15 min. to effect.
  • Caution: commonly see vomiting.

Injectable Chemical Restraint-Cats

  • For young fractious cats-dexmedetomidine (10–20 µg/kg) OR acepromazine (0.1 mg/kg) + ketamine (3–5 mg/kg) + opioid (butorphanol* 0.2 mg/kg or morphine 0.2 mg/kg) IM.
  • Alternative option-Telazol (tiletamine/zolazepam) 5–10 mg/kg IM.
  • For geriatric fractious cats-acepromazine (0.05 mg/kg) OR dexmedetomidine (5–10 µu/kg) + ketamine (3–5 mg/kg) + opioid (butorphanol* 0.2 mg/kg) IM.
  • Reverse dexmeditomidine with half volume of atipamezole to volume of dexmedetomidine administered IM; in ketamine protocols wait 30–60 min to reverse.

*Full Mu opioid agonist, ex. morphine (0.2 mg/kg), hydromorphone (0.05–0.1 mg/kg), or oxymorphone (0.1 mg/kg) is superior for pain management.

Oral Transmucosal-Cats

  • For healthy fractious cats-dexmedetomidine (40 µg/kg) + buprenorphine (0.02 mg/kg) OTM. Reverse dexmeditomidine with fourth-half volume of atipamezole to volume of total dexmedetomidine administered IM or SC.
  • Additional IM injection may be required.

Protocols courtesy R. Bednarski, DVM, MS, DACVA

Oral Sedative/Anxiolytics

Administer 90 min. prior to travel to relieve mild to moderate fearful/fractious behavior or help patient cope with injectable sedation. Doses should be repeated Q8-12hr PRN for inpatients.

Dogs

  • Trazodone: 4.0–18.0 mg/kg PO; not exceeding 300 mg per dose.
  • Clonidine: 0.01–0.05 mg/kg PO; can be combined with trazodone and/or benzodiazepines.
  • Acepromazine: 0.55–2.2 mg/kg PO; best in combination with trazodone, gabapentin, or benzodiazepine; avoid as sole agent, doesn't provide anxiolysis.
  • Lorazepam: 0.05–0.5 mg/kg PO.
  • Diazepam: 0.5–2.2 mg/kg PO.
  • Gabapentin: 20–40 mg/kg PO; can combine with trazodone, acepromazine, benzodiazepines.

Cats

  • Acepromazine: 1.1–2.2 mg/kg PO.
  • Lorazepam: 0.05–0.25 mg/kg PO; can combine with acepromazine.
  • Gabapentin: 10–20 mg/kg PO; can combine with acepromazine.
  • Buprenorphine: 0.01–0.03 mg/kg OTM.

Contraindications

Cats-avoid oral diazepam; acute hepatic necrosis reported.

Precautions

  • Agitation, gastrointestinal upset, heavy sedation, changes in appetite are potential side effects of all of above oral medications. Always have client perform drug trial at home to determine response and ideal dose.
  • Benzodiazepines-caution in fractious patients; disinhibition of aggression possible. Avoid in patients with a history of aggression in the home environment.

Possible Interactions

Avoid combining oral acepromazine with clonidine due to potential for serious fluctuations in blood pressure.

Alternative Drugs

Neutraceuticals: Harmonese, Anxitane, Zylkene, Composure. Additional medications likely required.

Follow-Up

Follow-Up

Patient Monitoring

Evaluate physiologic and behavioral parameters for evidence of stress response activation, and maintenance of normal physiologic and behavioral parameters. Long-term efficacy evidenced by reduced fear and increased affiliative behavior at subsequent visits (i.e., behavior improves with each handling bout).

Prevention/Avoidance

  • Prevention is key. It is more effective, less expensive, faster, and easier to avoid problematic behavior.
  • Client education-proper socialization of puppies and kittens, acclimate to a travel, DS/CC to handling.
  • Refer clients to science-based humane written, online, and direct referrals.
  • Low-stress handling and CC during all puppy and kitten sequential vaccination visits and adult visits.
  • “Happy visits” (DS/CC) for puppies and kittens between sequential vaccine visits, and for adults after intense or multiple sick visits or hospitalization.
  • Offer well-managed, positive puppy and kitten classes at your hospital.

Possible Complications

Animals with fearful and/or aggressive behavior are not able to effectively receive routine wellness care, diagnostic testing, advanced treatments or hospitalization, jeopardizing overall physical wellness.

Expected Course and Prognosis

N/A

Miscellaneous

Miscellaneous

Associated Conditions

Pets displaying fearful or fractious behavior in a veterinary setting often have comorbid behavioral problems in the home environment, including aggression to owners or strangers, leash reactivity, resource guarding, and anxiety disorders. Opening a dialog with clients, screening for these behavioral issues, and effectively triaging them will promote the patient's overall behavioral wellness and handling.

Age-Related Factors

  • Socialization period-3–12 wks (dogs), 2–7 wks (cats); this is the period where early exposure can minimize fear. A few sessions of exposure to the veterinary setting, staff, and restraint during this time paired with a positive experience (food) can lead to less fear and improved acceptance of future handling.
  • Fear period-8–10 wks. of age and between 4 and 11 mo. of age (dogs; unknown for cats). Susceptible to single-event learning, highly sensitive to negative experiences. Single frightening veterinary visit during this time frame can result in fear of setting, handling, or personnel.
  • Social maturity-reached at 2–4 y of age (dogs), 1–2 y (cats); period where animals develop mature social behaviors. Dogs who are fearful as puppies or adolescents often may not show first signs of aggression until this time. Essential to recognize signs of fear in juvenile and/or adolescent so a plan to CC a positive emotional response to the veterinary clinic, handling, and procedures can be established before aggression develops.

Zoonotic Potential

Bite wounds and associated infections are a zoonotic potential.

Pregnancy/Fertility/Breeding

Fearful and aggressive temperaments may be heritable and predispose to veterinary clinic fear.

Synonyms

Fear-related aggression, defensive aggression, pain related aggression, phobic behavior, fearful behavior

See Also

  • Fears, Phobias and Anxieties-Dogs
  • Fears, Phobias and Anxieties-Cats

Abbreviations

  • CC = counterconditioning
  • DS = desensitization
  • OTM = oral transmucosal

Authors Meghan E. Herron and Traci A. Shreyer

Consulting Editor Gary M. Landsberg

Client Education Handout Available Online

Suggested Reading

Herron M, Shreyer T. The pet friendly veterinary practice: a guide for practitioners. Vet Clin North Am Small Anim Pract 2014, 44:451481.

Hetts S.Pet behavior protocols: what to say, what to do, when to refer. Lakewood, CO: AAHA Press, 1999.

Landsberg G, Hunthausen W, Ackerman L, eds. Behavior Problems of the Dog and Cat. 3rd ed., Edinburgh, Saunders Elsevier, 2013.

Yin S. Low stress handling, restraint, and behavior modification of dogs and cats. Davis, CA: Cattle Dog Publishing, 2009.