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Table 1

Summary of Lesions Resulting in Horner's Syndrome

Lesion locationCausesCommon concurrent neurologic abnormalitiesDiagnostic plan
BrainstemNeoplasia, encephalitis, vascular, traumaAltered mental status, ipsilateral hemiparesis, ipsilateral postural reaction deficitsMRI; CSF analysis
C1–T3 spinal cordIVDH, trauma, neoplasia, FCEIpsilateral or bilateral hemiparesis/plegia, ± reduced reflexes to thoracic limbs, normal mentationMRI preferred, myelogram also may show lesion. CSF analysis
T1–T3 nerve rootsBrachial plexus avulsion, peripheral nerve tumor (lymphoma, nerve sheath tumor most common)Ipsilateral loss of thoracicl imb reflexes,ipsilateral loss of cutneous trunci, ipsilateral monoparesis/plegai, absent postural reactions in affected thoracic limb onlyMRI, electrodiagnostic testing
Sympathetic trunk, cranial cervical ganglion*Trauma, iatrogenic following jugular venipuncture, mediastinal or thyroid neoplasiaPossibly laryngeal dysfunctionNeck ultrasound, MRI, thoracic radiographs
Tympanic bullaOtitis media, polyp (cat), neoplasia, traumaIpsilateral vestibular disease, ipsilateral facial nerve paralysisMRI, CT, bulla radiographs, myringotomy
RetrobulbarNeoplasia, abcess, traumaNone, or dysfunction of CN II, III, IV, and VI.MRI, orbital ultrasound